2. Metabolic Enzyme/Protease
  3. Tyrosinase Endogenous Metabolite
  4. 2-Ketoglutaric acid-d6

2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

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2-Ketoglutaric acid-d<sub>6</sub> Chemical Structure

2-Ketoglutaric acid-d6 Chemical Structure

CAS No. : 1173021-86-7

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Other Forms of 2-Ketoglutaric acid-d6:

2-Ketoglutaric acid-d6 Related Antibodies

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Description

2-Ketoglutaric acid-d6 is the deuterium labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Ketoglutaric acid-d6 Related Antibodies
Molecular Weight

152.14

Formula

C5D6O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[2H]OC(C([2H])([2H])C([2H])([2H])C(C(O[2H])=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1643.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.5729 mL 32.8645 mL 65.7289 mL
5 mM 1.3146 mL 6.5729 mL 13.1458 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.5729 mL 32.8645 mL 65.7289 mL 164.3223 mL
5 mM 1.3146 mL 6.5729 mL 13.1458 mL 32.8645 mL
10 mM 0.6573 mL 3.2864 mL 6.5729 mL 16.4322 mL
15 mM 0.4382 mL 2.1910 mL 4.3819 mL 10.9548 mL
20 mM 0.3286 mL 1.6432 mL 3.2864 mL 8.2161 mL
25 mM 0.2629 mL 1.3146 mL 2.6292 mL 6.5729 mL
30 mM 0.2191 mL 1.0955 mL 2.1910 mL 5.4774 mL
40 mM 0.1643 mL 0.8216 mL 1.6432 mL 4.1081 mL
50 mM 0.1315 mL 0.6573 mL 1.3146 mL 3.2864 mL
60 mM 0.1095 mL 0.5477 mL 1.0955 mL 2.7387 mL
80 mM 0.0822 mL 0.4108 mL 0.8216 mL 2.0540 mL
100 mM 0.0657 mL 0.3286 mL 0.6573 mL 1.6432 mL
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2-Ketoglutaric acid-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Ketoglutaric acid-d61173021-86-7TyrosinaseEndogenous MetaboliteInhibitorinhibitorinhibit

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