2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK Neuronal Signaling
  3. Tyrosinase Trk Receptor
  4. Paltimatrectinib

Paltimatrectinib  (Synonyms: PBI-200; PPI-5278)

Cat. No.: HY-145587 Purity: 99.96%
COA Handling Instructions

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Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases.

For research use only. We do not sell to patients.

Paltimatrectinib Chemical Structure

Paltimatrectinib Chemical Structure

CAS No. : 2353522-15-1

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1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1250 In-stock
50 mg USD 1950 In-stock
100 mg USD 3200 In-stock
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Based on 1 publication(s) in Google Scholar

Paltimatrectinib Related Antibodies

Top Publications Citing Use of Products

View All Trk Receptor Isoform Specific Products:

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TrkA TrkB TrkC Trk

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Description

Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases[1].

IC50 & Target[1]

TrkA

 

Molecular Weight

434.37

Formula

C20H15F5N6
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

FC(F)(C1=CN(N=C1)C2=C3N(C=CC(N4[C@](C5=C(C=CC(F)=C5)F)([H])CCC4)=N3)N=C2)F
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (57.55 mM; ultrasonic and warming and heat to 75°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3022 mL 11.5109 mL 23.0218 mL
5 mM 0.4604 mL 2.3022 mL 4.6044 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.96%

COA (257 KB) HNMR (294 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3022 mL 11.5109 mL 23.0218 mL 57.5546 mL
5 mM 0.4604 mL 2.3022 mL 4.6044 mL 11.5109 mL
10 mM 0.2302 mL 1.1511 mL 2.3022 mL 5.7555 mL
15 mM 0.1535 mL 0.7674 mL 1.5348 mL 3.8370 mL
20 mM 0.1151 mL 0.5755 mL 1.1511 mL 2.8777 mL
25 mM 0.0921 mL 0.4604 mL 0.9209 mL 2.3022 mL
30 mM 0.0767 mL 0.3837 mL 0.7674 mL 1.9185 mL
40 mM 0.0576 mL 0.2878 mL 0.5755 mL 1.4389 mL
50 mM 0.0460 mL 0.2302 mL 0.4604 mL 1.1511 mL
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Paltimatrectinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Paltimatrectinib2353522-15-1PBI-200 PPI-5278PBI200PBI 200PPI5278PPI 5278PPI-5278TyrosinaseTrk ReceptorTropomyosin related kinase receptorInhibitorinhibitorinhibit

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