iGluR Antagonist

iGluR Antagonists (144):

Cat. No.	Product Name	Effect	Purity

HY-B0591

Memantine	Antagonist	99.89%
Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD).

HY-W018061C

(R,R)-Traxoprodil	Antagonist	99.00%
(R,R)-Traxoprodil is the the (R,R)-enantiomer of Traxoprodil (HY-W018061). Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC₅₀ of 10 nM.

HY-107602

UBP310	Antagonist	99.94%
UBP310 is a selective GluR5 antagonist, with a K_d of 130 nM.

HY-114427

NS-102	Antagonist	98.23%
NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist.

HY-17030

Acamprosate calcium	Antagonist	≥98.0%
Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction.

HY-124569

NAB-14	Antagonist
NAB-14 is a potent, selective, orally active and non-competitive GluN2C/2D antagonists with an IC₅₀ of 580 nM for GluN1/GluN2D. NAB-14 shows >800-fold selective for recombinant GluN2C and GluN2D over GluN2A and GluN2B. NAB-14 can cross the blood-brain-barrier.

HY-14777

Radiprodil	Antagonist	99.16%
Radiprodil (RGH-896) is an orally active and selective NMDA NR2B antagonist. A potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions.

HY-107606A

UBP301 hydrochloride	Antagonist
UBP301 hydrochloride is a potent and selective antagonist of kainate receptor with IC₅₀ and K_D of 164 μM and 5.94 μM, respectively. UBP301 hydrochloride has ～30-fold selectivity of kainate receptor over AMPA receptor. UBP301 hydrochloride is the derivative of willardiine.

HY-100806R

Kynurenic acid (Standard)	Antagonist
Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.

HY-107601

UBP316	Antagonist	99.95%
UBP316 (ACET) is a highly potent and selective kainate receptor GluK1 (GluR5) antagonist, with a K_b value of 1.4 nM. UBP316 is effective at blocking the depression of both field excitatory postsynaptic potentials (fEPSPs) and monosynaptically-evoked GABAergic transmission induced by ATPA, a GluK1 selective agonist.

HY-107706

Co 101244 hydrochloride	Antagonist	99.87%
Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist.

HY-N0215S5

L-Phenylalanine-¹⁵N	Antagonist	98.10%
L-Phenylalanine-¹⁵N is the ¹⁵N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals[1][2][3][4].

HY-106441A

Rislenemdaz	Antagonist	99.86%
Rislenemdaz (CERC-301) is an orally bioavailable and selective N-methyl-D-aspartate (NMDA) receptor subunit 2B (GluN2B) antagonist with K_i and IC₅₀ of 8.1 nM and 3.6 nM, respectively.

HY-142066

4′-Demethylnobiletin	Antagonist	99.78%
4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling.

HY-136299

Sepimostat	Antagonist	98.00%
Sepimostat (FUT-187 free base) exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat inhibits the Ifenprodil binding with a K_i value of 27.7?μM.

HY-107711

DQP-1105	Antagonist	98.10%
DQP-1105 is a potent noncompetitive NMDA receptor antagonist. DQP-1105 inhibits GluN2C- and GluN2D-containing receptors (IC₅₀=7.0 and 2.7 μM, respectively). The IC₅₀ values are at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, GluA1-, or GluK2-containing receptors.

HY-15086

Selfotel	Antagonist	99.67%
Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA)-preferring receptor. CGS 19755 inhibits the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type receptors with an IC₅₀ of 50 nM.

HY-N0215R

L-Phenylalanine (Standard)	Antagonist
L-Phenylalanine (Standard) is the analytical standard of L-Phenylalanine. This product is intended for research and analytical applications. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.

HY-107604

UBP 302	Antagonist	99.75%
UBP 302 is a potent and selective GLUK5-subunit containing kainate receptor antagonist (apparent K_d=402 nM), and displays very little affinity on GluK2 (GluR6) kainate receptors. Anxiolytic effects.

HY-150138

Gavestinel	Antagonist
Gavestinel (GV 150526) is a selective and potent the glycine site of the NMDA receptor antagonist. Gavestinel has neuroprotectant effects.

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