2. Membrane Transporter/Ion Channel Neuronal Signaling
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  4. Memantine

Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD).

For research use only. We do not sell to patients.

Memantine Chemical Structure

Memantine Chemical Structure

CAS No. : 19982-08-2

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5 mg USD 110 In-stock
10 mg USD 176 In-stock
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Based on 6 publication(s) in Google Scholar

Memantine Related Antibodies

Top Publications Citing Use of Products

    Memantine purchased from MedChemExpress. Usage Cited in: Neurochem Res. 2018 Oct;43(10):2008-2015.  [Abstract]

    Memantine inhibits the elevated levels of protein P-MARCKS induced by Aβ1-42 oligomers.

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    AMPA Receptor NMDA Receptor Kainate Receptor

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].

    In Vivo

    Memantine (1, 5 and 10, 15 mg/kg; i.p.; daily for 15-20 days) significantly decreased the large LTP recorded in hippocampal slices from aged animals[2].
    Memantine (1-3 mg/kg; per os (p.o.)) for 14 days significantly improves depressive-like behaviors in olfactory bulbectomized (OBX) mice, as assessed using the tail-suspension and forced-swim tests[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male Wistar rats[2]
    Dosage: 1, 5 and 10, 15 mg/kg
    Administration: i.p.; daily for 15-20 days
    Result: Significantly decreased the large LTP recorded in hippocampal slices from aged animals.
    Molecular Weight

    179.30

    Formula

    C12H21N
    CAS No.
    Appearance

    Solid

    Color

    Off-white to yellow

    SMILES

    N[C@]12C[C@@]3(C)C[C@](C2)(C)C[C@@H](C1)C3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    DMSO : 10 mg/mL (55.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.5772 mL 27.8862 mL 55.7724 mL
    5 mM 1.1154 mL 5.5772 mL 11.1545 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 1 mg/mL (5.58 mM); Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 1 mg/mL (5.58 mM); Clear solution

      This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.81%

    COA (251 KB) HNMR (208 KB) RP-HPLC (246 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 5.5772 mL 27.8862 mL 55.7724 mL 139.4311 mL
    5 mM 1.1154 mL 5.5772 mL 11.1545 mL 27.8862 mL
    10 mM 0.5577 mL 2.7886 mL 5.5772 mL 13.9431 mL
    15 mM 0.3718 mL 1.8591 mL 3.7182 mL 9.2954 mL
    20 mM 0.2789 mL 1.3943 mL 2.7886 mL 6.9716 mL
    25 mM 0.2231 mL 1.1154 mL 2.2309 mL 5.5772 mL
    30 mM 0.1859 mL 0.9295 mL 1.8591 mL 4.6477 mL
    40 mM 0.1394 mL 0.6972 mL 1.3943 mL 3.4858 mL
    50 mM 0.1115 mL 0.5577 mL 1.1154 mL 2.7886 mL
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    Memantine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Memantine19982-08-2iGluRIonotropic glutamate receptorsLTPhippocampalAlzheimer'sdiseasedepressiveInhibitorinhibitorinhibit

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