2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128144
    Lalistat 2
    		99.90%
    Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .
    Lalistat 2
  • HY-101509
    HSL-IN-1
    		Inhibitor 98.84%
    HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability.
    HSL-IN-1
  • HY-117549
    Ibrolipim
    		Activator 99.30%
    Ibrolipim (NO-1886) is an orally active lipoprotein lipase (LPL)-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects.
    Ibrolipim
  • HY-Y1422
    Triacylglycerol lipase
    Triacylglycerol lipase is an enzyme that preferentially hydrolyzes the outer links of triacylglycerols and acts only on the water-lipid interface. Pancreatic triacylglycerol lipase is the single most important determinant of lipid absorption.
    Triacylglycerol lipase
  • HY-153523
    Hi 76-0079
    		Inhibitor 99.90%
    Hi 76-0079 (Compound 31) is a hormone-sensitive lipase (HSL) inhibitor with an IC50 of 184 nM.
    Hi 76-0079
  • HY-Y1422D
    Lipase 435
    Lipase 435, an immobilized lipase derived from Candida antarctica fraction B, shows extensive industrial application in producing enantiopure pharmaceuticals, functional lipids, biodiesel, etc. .
    Lipase 435
  • HY-164714
    HSL-IN-5
    		Inhibitor 99.83%
    HSL-IN-5 (Example 21) is a hormone sensitive lipase (HSL) inhibitor (IC50: 0.25 μM). HSL-IN-5 can be used for diabetes research.
    HSL-IN-5
  • HY-Y1422E
    Lipase AS
    Lipase AS comes from Aspergillusniger and can be used for catalyzing chemical reactions.
    Lipase AS
  • HY-102056
    BAY 59-9435
    		Inhibitor 98.30%
    BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.
    BAY 59-9435
  • HY-23524
    HSL-IN-3
    		Inhibitor ≥98.0%
    HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL).
    HSL-IN-3
  • HY-148755
    ERX-41
    		99.81%
    ERX-41 is an orally active and stereospecific small molecule targeting to lysosomal acid lipase A (LIPA). ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, indicating a function independent of LIPA but dependent on its ER localization. ERX-41 involves in a targeted strategy for solid tumors.
    ERX-41
  • HY-14471
    Cetilistat
    		Inhibitor ≥98.0%
    Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
    Cetilistat
  • HY-103372
    GSK264220A
    		Inhibitor 99.24%
    GSK264220A is a potent endothelial lipase inhibitor with IC50 of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease.
    GSK264220A
  • HY-W099648
    4-Methylumbelliferyl octanoate
    		99.82%
    4-Methylumbelliferyl octanoate is a octoate. 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase.
    4-Methylumbelliferyl octanoate
  • HY-N0618
    Sanggenon D
    		Inhibitor 99.76%
    Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.
    Sanggenon D
  • HY-N7668
    Neotheaflavin
    		Inhibitor 99.61%
    Neotheaflavin, from black tea, inhibits pancreatic lipase.
    Neotheaflavin
  • HY-N0555
    Escin IB
    		Inhibitor 99.93%
    Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.
    Escin IB
  • HY-112911
    Endothelial lipase inhibitor-1
    		Inhibitor 98.02%
    Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
    Endothelial lipase inhibitor-1
  • HY-131999
    3,4,5-Trihydroxycinnamic acid decyl ester
    		Inhibitor 98.28%
    3,4,5-Trihydroxycinnamic acid decyl ester is an excellent inhibitor of lipid absorption and accumulation, with anti-obesity properties. 3,4,5-Trihydroxycinnamic acid decyl ester is a pancreatic lipase inhibitor, with an EC50 of approximately 0.9 μM.
    3,4,5-Trihydroxycinnamic acid decyl ester
  • HY-135996
    Dilaurylglycerosulfate
    Dilaurylglycerosulfate is a co-emulsifier in the diagnostic test for the determination of lipase.
    Dilaurylglycerosulfate
Cat. No. Product Name / Synonyms Application Reactivity