2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuropeptide FF Receptor
  5. Neuropeptide FF Receptor Isoform

Neuropeptide FF Receptor

 

Neuropeptide FF Receptor Related Products (10):

Cat. No. Product Name Effect Purity
  • HY-P1248
    Neuropeptide FF
    		98.80%
    Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation.
  • HY-124680
    AC-263093 free base
    		Inhibitor 99.81%
    AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research.
    .
  • HY-154829A
    AC-099 hydrochloride
    		Agonist 99.92%
    AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats.
  • HY-P10379
    palm-PrRP31
    		Agonist
    palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC50=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure.
  • HY-P3873
    Neuropeptide FF (5-8)
    Neuropeptide FF (5-8) is a Neuropeptide FF (HY-P1248)-related peptide. Neuropeptide FF (5-8) with a sequence of Q-P-Q-R-F-NH2 and a Ki value of 20.9 nM.
  • HY-P10780
    RFRP-3 (mouse)
    		Modulator
    RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development.
  • HY-P3945
    Prolactin-Releasing Peptide (12-31), bovine
    Prolactin-Releasing Peptide (12-31), bovine is a peptide fragment of prolactin-releasing peptide (PrRP). PrRP is RF-amide peptides expressed in brain areas involved in pain modulation. Prolactin-Releasing Peptide (12-31), bovine can be used for the research of nervous system disease.
  • HY-P10380
    palm11-PrRP31
    		Agonist
    palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction.
  • HY-154829
    AC-099
    		Agonist
    AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats.
  • HY-161382
    NPFF2-R ligand 1
    		Ligand
    NPFF2-R ligand 1 (Compound 16a) is a NPFF2-R ligand, with Kis of 228 and 27 nM for NPFF1-R and NPFF2-R respectively. NPFF2-R ligand 1 can be used for research related with central nervous system.