2. Signaling Pathways
  3. Anti-infection
  4. TMV

TMV

Tobacco mosaic virus

Tobacco mosaic virus (TMV) is named for one of the first plants in which it was found in the 1886. TMV can infect well over 350 different species of plants, many of which are favorites in home gardens such as tomatoes and potatoes. However TMV exclusively infects plants and is completely harmless for mammals. The rod-shaped virus particles (virions) of TMV measure about 300 nm x 15 nm. A single TMV particle is composed of 2,130 copies of the coat protein (CP) that envelope the RNA molecule of about 6,400 nucleotides. This single-stranded RNA encodes four genes: two replicase-associated proteins that are directly translated from the TMV RNA, and the movement protein and a coat protein that are translated from subgenomic RNAs. TMV is the textbook example for self-assembly. The assembly of the CPs (with or without RNA) to viruslike tubes is becoming an attractive way for nanoscale construction.

TMV Related Products (32):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-163201
    TMV-IN-7
    		Inhibitor
    TMV-IN-7 (compound G2) is a potent inhibitor of tobacco mosaic virus (TMV). TMV-IN-7 exhibits strong hydrophobic interactions to obstructing the virus’s self-assembly.
    TMV-IN-7
  • HY-N8521
    6-O-Methacrylate
    6-O-Methacrylate, a trilobolide, is isolated from the leaves of Wedelia trilobata. 6-O-Methacrylate displays marked antimalarial activity, with IC50 of 8.9 μg/mL against P. falciparum parasite. 6-O-Methacrylate also has anti-tobacco mosaic virus (TMV) activity.
    6-O-Methacrylate
  • HY-162400
    TMV-IN-8
    		Inhibitor
    TMV-IN-8 (compound 7 d) is an anti tobacco mosaic virus (TMV) agent with an antiviral EC50 of 157.6 μg/mL.TMV-IN-8 blocks the assembly of TMV by binding with coat protein (Kd = 0.7 μM) and suppressed TMV coat protein gene expression and biosynthesis process.
    TMV-IN-8
  • HY-163999
    TMV-IN-12
    		Inhibitor
    TMV-IN-12 (compound 4) is an inhibitor of tobacco mosaic virus (TMV) with antifungal properties. TMV-IN-12 effectively prevents TMV particle aggregation and self-assembly of TMV capsid protein (TMV-CP) (Kd=0.142 μM), preventing TMV from infecting tobacco plants.
    TMV-IN-12
  • HY-P10562
    BMV Gag-(7−25)
    BMV Gag-(7?25) is an arginine-rich peptide with cell-penetrating ability. BMV Gag-(7?25) can be used in drug delivery and gene therapy research.
    BMV Gag-(7−25)
  • HY-N7194
    Yadanzioside L
    Yadanzioside L is a quassinoid and shows anti-tobacco mosaic virus (TMV) activity (IC50=4.86 μM).
    Yadanzioside L
  • HY-148567
    TMV-IN-1
    		Inhibitor
    TMV-IN-1, chalcone derivative, is a tobacco mosaic virus (TMV) inhibitor. TMV-IN-1 has good therapeutic activity and protective activity against TMV with EC50 values of 70.7 μg/mL and 60.8 μg/mL, respectively. TMV-IN-1 can be used for the research of infection, inflammation and tumor.
    TMV-IN-1
  • HY-119458
    Luotonin A
    		Inhibitor
    Luotonin A is an antiviral and antiphytopathogenic fungus agent. Luotonin A has good antiviral activity against tobacco mosaic virus (TMV). Luotonin A also has certain inhibitory activity on topoisomerase I and topoisomerase II. Luotonin A shows antitumor activity.
    Luotonin A
  • HY-W718796
    DL-Serine-15N
    DL-Serine-15N is 15N-labeled DL-Serine (HY-Y0507) DL-Serine, a fundamental metabolite, is a mixture of D-Serine and L-Serine. DL-Serine has antiviral activity against the multiplication of tobacco mosaic virus (TMV).
    DL-Serine-<sup>15</sup>N
  • HY-161955
    TMV-IN-11
    		Inhibitor
    TMV-IN-11 (compound syn-3g) is a potent TMV inhibitor with high inactivation capacity (IC50: 120.7 μg/mL). TMV-IN-11 can effectively inhibit the expression of TMV.
    TMV-IN-11
  • HY-169186
    TMV-IN-13
    		Inhibitor
    TMV-IN-13 (compund 5g) has anti-TMV activity.
    TMV-IN-13
  • HY-163754
    TMV-IN-9
    		Inhibitor
    TMV-IN-9 (compound A6) is an antiviral agent that displays excellent inactivating against tobacco mosaic virus (TMV) with an EC50 of 62.8 μg/mL. TMV-IN-9 shows strong binding capacity to TMV coat protein with a binding affinity value of 1.862 μM. TMV-IN-9 obviously destroys the integrity of the TMV particles and blocked the virus from infecting the host.
    TMV-IN-9