2. PI3K/Akt/mTOR
  3. PI3K
  4. Tenalisib R Enantiomer

Tenalisib R Enantiomer  (Synonyms: RP6530 R Enantiomer)

Cat. No.: HY-112172 Purity: 99.63%
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Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively.

For research use only. We do not sell to patients.

Tenalisib R Enantiomer Chemical Structure

Tenalisib R Enantiomer Chemical Structure

CAS No. : 1639417-54-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 352 In-stock
Solution
10 mM * 1 mL in DMSO USD 352 In-stock
Solid
5 mg USD 320 In-stock
10 mg USD 495 In-stock
25 mg USD 850 In-stock
50 mg USD 1280 In-stock
100 mg USD 1950 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Tenalisib R Enantiomer:

Tenalisib R Enantiomer Related Antibodies

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

Tenalisib R Enantiomer (RP6530 R Enantiomer) is an R enantiomer of Tenalisib. Tenalisib is a potent and selective PI3Kδ and PI3Kγ inhibitor with IC50 values of 25 and 33 nM, respectively[1][2].

In Vitro

Tenalisib, a dual PI3K δ/γ inhibitor, potentiates Ruxolitinib activity in the JAK2-V617F mutant erythroleukemia cell lines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tenalisib R Enantiomer Related Antibodies
Molecular Weight

415.42

Formula

C23H18FN5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C2=CC=CC(F)=C2)=C([C@H](NC3=C4N=CNC4=NC=N3)CC)OC5=CC=CC=C15
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (240.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4072 mL 12.0360 mL 24.0720 mL
5 mM 0.4814 mL 2.4072 mL 4.8144 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4072 mL 12.0360 mL 24.0720 mL 60.1801 mL
5 mM 0.4814 mL 2.4072 mL 4.8144 mL 12.0360 mL
10 mM 0.2407 mL 1.2036 mL 2.4072 mL 6.0180 mL
15 mM 0.1605 mL 0.8024 mL 1.6048 mL 4.0120 mL
20 mM 0.1204 mL 0.6018 mL 1.2036 mL 3.0090 mL
25 mM 0.0963 mL 0.4814 mL 0.9629 mL 2.4072 mL
30 mM 0.0802 mL 0.4012 mL 0.8024 mL 2.0060 mL
40 mM 0.0602 mL 0.3009 mL 0.6018 mL 1.5045 mL
50 mM 0.0481 mL 0.2407 mL 0.4814 mL 1.2036 mL
60 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0030 mL
80 mM 0.0301 mL 0.1505 mL 0.3009 mL 0.7523 mL
100 mM 0.0241 mL 0.1204 mL 0.2407 mL 0.6018 mL
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Tenalisib R Enantiomer Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tenalisib R Enantiomer1639417-54-1RP6530 R EnantiomerPI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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