Tetrahydroberberine (Synonyms: Canadine)

Name: Tetrahydroberberine
Brand: MedChemExpress
SKU: HY-N0925
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0925 Purity: 98.61%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach.

For research use only. We do not sell to patients.

Tetrahydroberberine Chemical Structure

CAS No. : 522-97-4

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 45	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Tetrahydroberberine:

(S)-(-)-Tetrahydroberberine Get quote
(R)-(+)-Tetrahydroberberine Get quote
Tetrahydroberberine (Standard) Get quote

1 Publications Citing Use of MCE Tetrahydroberberine

•J Agric Food Chem. 2024 Sep 5. [Abstract]

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 30 μM Compound: 9	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 20594848]
HCT-15	IC₅₀	> 30 μM Compound: 9	Cytotoxicity against human HCT15 cells by SRB assay Cytotoxicity against human HCT15 cells by SRB assay	[PMID: 20594848]
PC-12	CC₅₀	> 150 μM Compound: 15	Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay Cytotoxicity against rat PC12 cells assessed as reduction in cell viability incubated for 24 hrs by WST-8 assay	[PMID: 33611188]
SK-MEL-2	IC₅₀	27.94 μM Compound: 9	Cytotoxicity against human SK-MEL-2 cells by SRB assay Cytotoxicity against human SK-MEL-2 cells by SRB assay	[PMID: 20594848]
SK-OV-3	IC₅₀	> 30 μM Compound: 9	Cytotoxicity against human SKOV3 cells by SRB assay Cytotoxicity against human SKOV3 cells by SRB assay	[PMID: 20594848]
THP-1	IC₅₀	8.35 nM Compound: 3	Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs	[PMID: 23199480]

In Vitro

Tetrahydroberberine (100 μM) blocks K(ATP) channels in sharply isolated dopaminergic (DA) neurons in rat substantia nigra pars compacta (SNc) and restores membrane hyperpolarization induced by 1 μM rotenone (HY-B1756)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tetrahydroberberine (30 μg/kg; IV) causes a dramatic increase in gastric regulatory capacity in beagle dogs, significantly enhances gastric contractility and shortens contraction intervals in rats, and enhances gastric motility function in the upper gastrointestinal tract^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

339.39

Formula

C₂₀H₂₁NO₄

CAS No.

522-97-4

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C(CC23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (73.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9465 mL	14.7323 mL	29.4646 mL
5 mM	0.5893 mL	2.9465 mL	5.8929 mL
10 mM	0.2946 mL	1.4732 mL	2.9465 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.61%

Select Batch:

Data Sheet (274 KB) SDS (392 KB)

COA (250 KB) HNMR (257 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24. [Content Brief]

[2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36. [Content Brief]

[3]. Wu C, et al. Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta. Neuropharmacology. 2010 Dec;59(7-8):567-72. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9465 mL	14.7323 mL	29.4646 mL	73.6616 mL
	5 mM	0.5893 mL	2.9465 mL	5.8929 mL	14.7323 mL
	10 mM	0.2946 mL	1.4732 mL	2.9465 mL	7.3662 mL
	15 mM	0.1964 mL	0.9822 mL	1.9643 mL	4.9108 mL
	20 mM	0.1473 mL	0.7366 mL	1.4732 mL	3.6831 mL
	25 mM	0.1179 mL	0.5893 mL	1.1786 mL	2.9465 mL
	30 mM	0.0982 mL	0.4911 mL	0.9822 mL	2.4554 mL
	40 mM	0.0737 mL	0.3683 mL	0.7366 mL	1.8415 mL
	50 mM	0.0589 mL	0.2946 mL	0.5893 mL	1.4732 mL
	60 mM	0.0491 mL	0.2455 mL	0.4911 mL	1.2277 mL

Tetrahydroberberine Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydroberberine522-97-4CanadineDopamine ReceptorInhibitorinhibitorinhibit

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Tetrahydroberberine (Synonyms: Canadine)

Customer Review

Other Forms of Tetrahydroberberine:

Tetrahydroberberine Related Antibodies

1 Publications Citing Use of MCE Tetrahydroberberine

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Tetrahydroberberine Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Tetrahydroberberine Related Classifications

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