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  6. (S)-(-)-Tetrahydroberberine

(S)-(-)-Tetrahydroberberine  (Synonyms: (-)-Canadine; (S)-(-)-Canadine)

Cat. No.: HY-N1418
Handling Instructions

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(S)-(-)-Tetrahydroberberine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity.

For research use only. We do not sell to patients.

(S)-(-)-Tetrahydroberberine Chemical Structure

(S)-(-)-Tetrahydroberberine Chemical Structure

CAS No. : 5096-57-1

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Based on 1 publication(s) in Google Scholar

Other Forms of (S)-(-)-Tetrahydroberberine:

(S)-(-)-Tetrahydroberberine Related Antibodies

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  • Purity & Documentation

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Description

(S)-(-)-Tetrahydroberberine is an alkaloid and intermediate in the biosynthesis of berberine with insecticidal activity[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
5.4 μM
Compound: 3
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assa
Antagonist activity at human full-length N-terminal SNAP-tagged alpha1A adrenoceptor expressed in HEK293 cells assessed as inhibition of agonist-induced calcium mobilization preincubated for 10 mins followed by agonist addition by fluo-4 AM dye-based assa
[PMID: 27709945]
KB IC50
> 734 μM
Compound: Canadine
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 11141105]
MRC5 IC50
12 μM
Compound: 9
Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
Antiviral activity against HCMV in MRC5 cells by plaque reduction assay
[PMID: 17239594]
Molecular Weight

339.39

Formula

C20H21NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C(C[C@]23[H])C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Acetone : ≥ 12.5 mg/mL (36.83 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9465 mL 14.7323 mL 29.4646 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Acetone 1 mM 2.9465 mL 14.7323 mL 29.4646 mL 73.6616 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL 14.7323 mL
10 mM 0.2946 mL 1.4732 mL 2.9465 mL 7.3662 mL
15 mM 0.1964 mL 0.9822 mL 1.9643 mL 4.9108 mL
20 mM 0.1473 mL 0.7366 mL 1.4732 mL 3.6831 mL
25 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9465 mL
30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4554 mL
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(S)-(-)-Tetrahydroberberine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-(-)-Tetrahydroberberine5096-57-1(-)-Canadine (S)-(-)-CanadineOthersInhibitorinhibitorinhibit

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