Urocortin, rat  (Synonyms: Urocortin (Rattus norvegicus); Rat urocortin)

Urocortin, rat (Urocortin (Rattus norvegicus)) is a neuropeptide and a potent endogenous CRFR agonist with K_is of 13 nM, 1.5 nM, and 0.97 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively^[1][2].

Urocortin, rat induces cyclic AMP (cAMP) generation with EC₅₀ of 0.15 nM, 0.063 nM, and 0.087 nM for human CRF₁, rat CRF_2α and mouse CRF_2β, respectively in stably transfected Chinese hamster ovary cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Urocortin, rat (0.01 to 10 μg) decreases food intake in both food-deprived and non-deprived rats and such an effect also observed in mice after 1 μg of Urocortin, rat i.c.v. administration. Urocortin, rat has the potential of inducing anxiogenic behavior^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4707.26

C₂₀6H_338N62O64

171543-83-2

Solid

White to off-white

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

DDPPLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

• [1]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.  [Content Brief]

  [2]. Skelton KH, et al. The neurobiology of urocortin. Regul Pept. 2000 Sep 25;93(1-3):85-92.  [Content Brief]

  [3]. Perrin MH, et al. Corticotropin releasing factor receptors and their ligand family. Ann N Y Acad Sci. 1999 Oct 20;885:312-28.  [Content Brief]