2. Apoptosis Metabolic Enzyme/Protease
  3. MDM-2/p53 E1/E2/E3 Enzyme Apoptosis
  4. YH239-EE

YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.

For research use only. We do not sell to patients.

YH239-EE Chemical Structure

YH239-EE Chemical Structure

CAS No. : 1364488-67-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 134 In-stock
Solution
10 mM * 1 mL in DMSO USD 134 In-stock
Solid
5 mg USD 78 In-stock
10 mg USD 122 In-stock
50 mg USD 487 In-stock
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Based on 1 publication(s) in Google Scholar

YH239-EE Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE YH239-EE

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  • References

  • Customer Review

Description

YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent. IC50 value: Target: MDM2/p53 YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).

Molecular Weight

504.41

Formula

C25H27Cl2N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 55 mg/mL (109.04 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9825 mL 9.9126 mL 19.8251 mL
5 mM 0.3965 mL 1.9825 mL 3.9650 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9825 mL 9.9126 mL 19.8251 mL 49.5629 mL
5 mM 0.3965 mL 1.9825 mL 3.9650 mL 9.9126 mL
10 mM 0.1983 mL 0.9913 mL 1.9825 mL 4.9563 mL
15 mM 0.1322 mL 0.6608 mL 1.3217 mL 3.3042 mL
20 mM 0.0991 mL 0.4956 mL 0.9913 mL 2.4781 mL
25 mM 0.0793 mL 0.3965 mL 0.7930 mL 1.9825 mL
30 mM 0.0661 mL 0.3304 mL 0.6608 mL 1.6521 mL
40 mM 0.0496 mL 0.2478 mL 0.4956 mL 1.2391 mL
50 mM 0.0397 mL 0.1983 mL 0.3965 mL 0.9913 mL
60 mM 0.0330 mL 0.1652 mL 0.3304 mL 0.8260 mL
80 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6195 mL
100 mM 0.0198 mL 0.0991 mL 0.1983 mL 0.4956 mL
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YH239-EE Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YH239-EE1364488-67-4MDM-2/p53E1/E2/E3 EnzymeApoptosisE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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