2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. A-61603

A-61603 is a selective α1A-adrenergic receptor agonist. A-61603 increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro.

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A-61603 Chemical Structure

A-61603 Chemical Structure

CAS No. : 107756-30-9

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5 mg USD 260 In-stock
10 mg USD 420 In-stock
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Based on 1 publication(s) in Google Scholar

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α adrenergic receptor β adrenergic receptor

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Description

A-61603 is a selective α1A-adrenergic receptor agonist[1]. A-61603 increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro[2].

IC50 & Target

α1A-adrenergic receptor

 

Molecular Weight

390.30

Formula

C14H20BrN3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=C2CCCC(C3=NCCN3)C2=CC=C1O)=O.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (51.24 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5621 mL 12.8107 mL 25.6213 mL
5 mM 0.5124 mL 2.5621 mL 5.1243 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5621 mL 12.8107 mL 25.6213 mL 64.0533 mL
5 mM 0.5124 mL 2.5621 mL 5.1243 mL 12.8107 mL
10 mM 0.2562 mL 1.2811 mL 2.5621 mL 6.4053 mL
15 mM 0.1708 mL 0.8540 mL 1.7081 mL 4.2702 mL
20 mM 0.1281 mL 0.6405 mL 1.2811 mL 3.2027 mL
25 mM 0.1025 mL 0.5124 mL 1.0249 mL 2.5621 mL
30 mM 0.0854 mL 0.4270 mL 0.8540 mL 2.1351 mL
40 mM 0.0641 mL 0.3203 mL 0.6405 mL 1.6013 mL
50 mM 0.0512 mL 0.2562 mL 0.5124 mL 1.2811 mL
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A-61603 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A-61603107756-30-9A61603A 61603Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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