2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. ADC Cytotoxin Topoisomerase
  4. Ac-Exatecan

Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM).

For research use only. We do not sell to patients.

Ac-Exatecan Chemical Structure

Ac-Exatecan Chemical Structure

CAS No. : 2922852-48-8

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10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Ac-Exatecan:

Ac-Exatecan Related Antibodies

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Topoisomerase Topo I Topo II

  • Biological Activity

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Description

Ac-Exatecan is acetylated Exatecan (HY-13631). Exatecan (DX-8951) is a common toxin component in ADC preparation (ADC Cytotoxin) and an inhibitor of DNA topoisomerase I (IC50=2.2 μM)[1].

IC50 & Target

Camptothecins

 

Molecular Weight

477.48

Formula

C26H24FN3O5
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(OC1)[C@@](CC)(O)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C([C@@H](NC(C)=O)CC6)=C4C3)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (209.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0943 mL 10.4716 mL 20.9433 mL
5 mM 0.4189 mL 2.0943 mL 4.1887 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0943 mL 10.4716 mL 20.9433 mL 52.3582 mL
5 mM 0.4189 mL 2.0943 mL 4.1887 mL 10.4716 mL
10 mM 0.2094 mL 1.0472 mL 2.0943 mL 5.2358 mL
15 mM 0.1396 mL 0.6981 mL 1.3962 mL 3.4905 mL
20 mM 0.1047 mL 0.5236 mL 1.0472 mL 2.6179 mL
25 mM 0.0838 mL 0.4189 mL 0.8377 mL 2.0943 mL
30 mM 0.0698 mL 0.3491 mL 0.6981 mL 1.7453 mL
40 mM 0.0524 mL 0.2618 mL 0.5236 mL 1.3090 mL
50 mM 0.0419 mL 0.2094 mL 0.4189 mL 1.0472 mL
60 mM 0.0349 mL 0.1745 mL 0.3491 mL 0.8726 mL
80 mM 0.0262 mL 0.1309 mL 0.2618 mL 0.6545 mL
100 mM 0.0209 mL 0.1047 mL 0.2094 mL 0.5236 mL
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Ac-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ac-Exatecan2922852-48-8ADC CytotoxinTopoisomeraseADC PayloadInhibitorinhibitorinhibit

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