2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE/BChE-IN-10

AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research.

For research use only. We do not sell to patients.

AChE/BChE-IN-10 Chemical Structure

AChE/BChE-IN-10 Chemical Structure

CAS No. : 2924824-48-4

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10 mg USD 135 In-stock
25 mg USD 280 In-stock
50 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

AChE/BChE-IN-10 Related Antibodies

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Description

AChE/BChE-IN-10 (Compound 7b) is a potent dual AChE and BChE inhibitor with IC50 values of 0.176, and 0.47 μM, respectively. AChE/BChE-IN-10 shows good blood brain barrier permeability. AChE/BChE-IN-10 can inhibit Aβ-aggregation and be used in Alzheimer’s disease (AD) research[1].

IC50 & Target[1]

AChE

0.176 μM (IC50)

BChE

0.47 μM (IC50)

In Vitro

AChE/BChE-IN-10 inhibits AChE in a non-competitive manner with Ki of 0.21 μM, and BChE in a mixed-fashion with Ki of 0.15 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BChE-IN-10 Related Antibodies
Molecular Weight

402.53

Formula

C26H30N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C4C=C(OC)C=CC4=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (62.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4843 mL 12.4214 mL 24.8429 mL
5 mM 0.4969 mL 2.4843 mL 4.9686 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4843 mL 12.4214 mL 24.8429 mL 62.1072 mL
5 mM 0.4969 mL 2.4843 mL 4.9686 mL 12.4214 mL
10 mM 0.2484 mL 1.2421 mL 2.4843 mL 6.2107 mL
15 mM 0.1656 mL 0.8281 mL 1.6562 mL 4.1405 mL
20 mM 0.1242 mL 0.6211 mL 1.2421 mL 3.1054 mL
25 mM 0.0994 mL 0.4969 mL 0.9937 mL 2.4843 mL
30 mM 0.0828 mL 0.4140 mL 0.8281 mL 2.0702 mL
40 mM 0.0621 mL 0.3105 mL 0.6211 mL 1.5527 mL
50 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2421 mL
60 mM 0.0414 mL 0.2070 mL 0.4140 mL 1.0351 mL
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AChE/BChE-IN-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE-IN-102924824-48-4Cholinesterase (ChE)blood brain barrier permeabilityAβ-aggregationAlzheimer’s diseaseADInhibitorinhibitorinhibit

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