AHN 1-055 hydrochloride (Synonyms: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride)

Name: AHN 1-055 hydrochloride
Brand: MedChemExpress
SKU: HY-101315
Rating: 4.5 (1 reviews)

Cat. No.: HY-101315 Purity: 99.96%: FAQs
Data Sheet SDS COA Handling Instructions

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AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC₅₀ of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT).

For research use only. We do not sell to patients.

AHN 1-055 hydrochloride Chemical Structure

CAS No. : 202646-03-5

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Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 60	In-stock	Estimated Time of Arrival: December 31
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10 mM * 1 mL in DMSO	USD 60	In-stock	Estimated Time of Arrival: December 31
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5 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 260	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE AHN 1-055 hydrochloride

•Arch Pharm (Weinheim). 2023 Jan;356(1):e2200371. [Abstract]

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Description

AHN 1-055 hydrochloride is a dopamine uptake inhibitor, with an IC₅₀ of 71 nM. AHN 1-055 hydrochloride binds with high affinity to the dopamine transporter (DAT)^[1].

IC₅₀ & Target

IC50: 71 nM (dopamine uptake)^[1]

In Vivo

AHN 1-055 (5 mg/kg; i.v.) inhibits the uptaking of brain dopamine with an IC₅₀ of 311.8 ng/ml in vivo^[1].
AHN 1-055 (10 mg/kg; i.v.) exhibits C^max of 1.48 mg/L and terminal elimination half-lives of 7.69 h due to 1.8L/h/kg plasma clearance combined with 18.7 L/kg volumes of distribution^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Sprague Dawley rats (250-275 g)^[1]
Dosage:	5 mg/kg (Pharmacokinetic Analysis)
Administration:	I.v. administration
Result:	C_max (1.48 mg/L); T_1/2 (7.69 h).

Molecular Weight

379.87

Formula

C₂₁H₂₄ClF₂NO

CAS No.

202646-03-5

Appearance

Solid

Color

White to yellow

SMILES

CN1[C@@H]2C[C@@H](OC(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)C[C@H]1CC2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (263.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 33.33 mg/mL (87.74 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6325 mL	13.1624 mL	26.3248 mL
5 mM	0.5265 mL	2.6325 mL	5.2650 mL
10 mM	0.2632 mL	1.3162 mL	2.6325 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.48 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.96%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (254 KB) RP-HPLC (251 KB)

Handling Instructions (2659 KB)

References

[1]. Sangeeta R, et, al. Investigation of the potential pharmacokinetic and pharmaco-dynamic drug interaction between AHN 1-055, a potent benztropine analog used for cocaine abuse, and cocaine after dosing in rats using intracerebral microdialysis. Biopharm Drug Dispos. 2006 Jul; 27(5): 229-40. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.6325 mL	13.1624 mL	26.3248 mL	65.8120 mL
	5 mM	0.5265 mL	2.6325 mL	5.2650 mL	13.1624 mL
	10 mM	0.2632 mL	1.3162 mL	2.6325 mL	6.5812 mL
	15 mM	0.1755 mL	0.8775 mL	1.7550 mL	4.3875 mL
	20 mM	0.1316 mL	0.6581 mL	1.3162 mL	3.2906 mL
	25 mM	0.1053 mL	0.5265 mL	1.0530 mL	2.6325 mL
	30 mM	0.0877 mL	0.4387 mL	0.8775 mL	2.1937 mL
	40 mM	0.0658 mL	0.3291 mL	0.6581 mL	1.6453 mL
	50 mM	0.0526 mL	0.2632 mL	0.5265 mL	1.3162 mL
	60 mM	0.0439 mL	0.2194 mL	0.4387 mL	1.0969 mL
	80 mM	0.0329 mL	0.1645 mL	0.3291 mL	0.8226 mL
DMSO	100 mM	0.0263 mL	0.1316 mL	0.2632 mL	0.6581 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

AHN 1-055 hydrochloride Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AHN 1-055202646-03-53α-Bis-(4-fluorophenyl) MethoxytropaneDopamine TransporterDATSLC6A3DopamineuptaketransporterInhibitorinhibitorinhibit

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AHN 1-055 hydrochloride (Synonyms: 3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride)

Customer Review

AHN 1-055 hydrochloride Related Antibodies

1 Publications Citing Use of MCE AHN 1-055 hydrochloride

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

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Dilution Calculator

Complete Stock Solution Preparation Table

AHN 1-055 hydrochloride Related Classifications

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