Alacepril (Synonyms: Cetapril; DU-1219)

Name: Alacepril
Brand: MedChemExpress
SKU: HY-107318
Rating: 4.5 (1 reviews)

Cat. No.: HY-107318 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Alacepril (Cetapril) is an orally active angiotensin converting enzyme (ACE) inhibitor with long lasting antihypertensive effect.

For research use only. We do not sell to patients.

Alacepril Chemical Structure

CAS No. : 74258-86-9

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Based on 1 publication(s) in Google Scholar

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Description

Alacepril (Cetapril) is an orally active angiotensin converting enzyme (ACE) inhibitor with long lasting antihypertensive effect^[1].

In Vivo

The long lasting antihypertensive effect of Alacepril in renal hypertensive rats is confirmed by once daily successive oral administration (1-2 mg/kg/d). In renal hypertensive dogs, Alacepril (3 mg/kg) showed a stable and sustained hypotensive effect, and its duration of action was longer than that of captopril^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

406.50

Formula

C₂₀H₂₆N₂O₅S

CAS No.

74258-86-9

Appearance

Solid

Color

White to off-white

SMILES

CC(SC[C@@H](C)C(N1[C@@H](CCC1)C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (246.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4600 mL	12.3001 mL	24.6002 mL
5 mM	0.4920 mL	2.4600 mL	4.9200 mL
10 mM	0.2460 mL	1.2300 mL	2.4600 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.15 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (6.15 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 2.5 mg/mL (6.15 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (271 KB) SDS (392 KB)

COA (247 KB)

Handling Instructions (2659 KB)

References

[1]. Takeyama K, et al. Antihypertensive activity of alacepril, an orally active angiotensin converting enzyme inhibitor, in renal hypertensive rats and dogs. Arzneimittelforschung. 1985;35(10):1502-1507. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4600 mL	12.3001 mL	24.6002 mL	61.5006 mL
	5 mM	0.4920 mL	2.4600 mL	4.9200 mL	12.3001 mL
	10 mM	0.2460 mL	1.2300 mL	2.4600 mL	6.1501 mL
	15 mM	0.1640 mL	0.8200 mL	1.6400 mL	4.1000 mL
	20 mM	0.1230 mL	0.6150 mL	1.2300 mL	3.0750 mL
	25 mM	0.0984 mL	0.4920 mL	0.9840 mL	2.4600 mL
	30 mM	0.0820 mL	0.4100 mL	0.8200 mL	2.0500 mL
	40 mM	0.0615 mL	0.3075 mL	0.6150 mL	1.5375 mL
	50 mM	0.0492 mL	0.2460 mL	0.4920 mL	1.2300 mL
	60 mM	0.0410 mL	0.2050 mL	0.4100 mL	1.0250 mL
	80 mM	0.0308 mL	0.1538 mL	0.3075 mL	0.7688 mL
	100 mM	0.0246 mL	0.1230 mL	0.2460 mL	0.6150 mL

Alacepril Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alacepril74258-86-9Cetapril DU-1219DU1219DU 1219DU-1219Angiotensin-converting Enzyme (ACE)orallong lastingantihypertensive effectInhibitorinhibitorinhibit

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Alacepril (Synonyms: Cetapril; DU-1219)

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Complete Stock Solution Preparation Table

Alacepril Related Classifications

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