ALDH1A inhibitor 673A (Synonyms: ALDH1Ai 673A)

Cat. No.: HY-122912 Purity: 99.15%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ALDH1A inhibitor 673A is an ALDH1A inhibitor. ALDH1A inhibitor 673A inhibits all three ALDH1A family members (IC₅₀: 246 nM, 230 nM, 348 nM for ALDH1A1, ALDH1A2, ALDH1A3 respectively. ALDH1A inhibitor 673A induces necroptotic cell death preferentially in CD133+ ovarian CSCs. ALDH1A inhibitor 673A also inhibits chemotherapy-resistant tumor growth.

For research use only. We do not sell to patients.

ALDH1A inhibitor 673A Chemical Structure

CAS No. : 109437-62-9

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
5 mg	USD 65	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 105	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 210	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 330	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 520	In-stock	Estimated Time of Arrival: December 31
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View All Aldehyde Dehydrogenase (ALDH) Isoform Specific Products:

View All Isoforms

ALDH1 ALDH2 ALDH3

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

223.27

Formula

C₁₅H₁₃NO

CAS No.

109437-62-9

Appearance

Solid

Color

Off-white to light brown

SMILES

O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 29.17 mg/mL (130.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.4789 mL	22.3944 mL	44.7888 mL
5 mM	0.8958 mL	4.4789 mL	8.9578 mL
10 mM	0.4479 mL	2.2394 mL	4.4789 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.15%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (245 KB) HNMR (237 KB) LCMS (92 KB)

Handling Instructions (2659 KB)

References

[1]. Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.4789 mL	22.3944 mL	44.7888 mL	111.9720 mL
	5 mM	0.8958 mL	4.4789 mL	8.9578 mL	22.3944 mL
	10 mM	0.4479 mL	2.2394 mL	4.4789 mL	11.1972 mL
	15 mM	0.2986 mL	1.4930 mL	2.9859 mL	7.4648 mL
	20 mM	0.2239 mL	1.1197 mL	2.2394 mL	5.5986 mL
	25 mM	0.1792 mL	0.8958 mL	1.7916 mL	4.4789 mL
	30 mM	0.1493 mL	0.7465 mL	1.4930 mL	3.7324 mL
	40 mM	0.1120 mL	0.5599 mL	1.1197 mL	2.7993 mL
	50 mM	0.0896 mL	0.4479 mL	0.8958 mL	2.2394 mL
	60 mM	0.0746 mL	0.3732 mL	0.7465 mL	1.8662 mL
	80 mM	0.0560 mL	0.2799 mL	0.5599 mL	1.3997 mL
	100 mM	0.0448 mL	0.2239 mL	0.4479 mL	1.1197 mL

ALDH1A inhibitor 673A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALDH1A inhibitor 673A109437-62-9ALDH1Ai 673AAldehyde Dehydrogenase (ALDH)NecroptosisOvarian cancertumorstem-like cellschemotherapy-resistantInhibitorinhibitorinhibit

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