ALK kinase inhibitor-1

Name: ALK kinase inhibitor-1
Brand: MedChemExpress
SKU: HY-19990
Rating: 4.5 (1 reviews)

Cat. No.: HY-19990 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor extracted from patent US20130261106A1 compound I-202.

For research use only. We do not sell to patients.

ALK kinase inhibitor-1 Chemical Structure

CAS No. : 1462949-64-9

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 72	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 195	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 295	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor extracted from patent US20130261106A1 compound I-202^[1].

Molecular Weight

537.65

Formula

C₂₈H₃₂FN₅O₃S

CAS No.

1462949-64-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

CN(CC1)CCN1C2=CC=C(NC3=NC=C4C(C(C5=C(OC)C=CC(F)=C5)=C(CO)S4)=N3)C(OC(C)C)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (185.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8599 mL	9.2997 mL	18.5995 mL
5 mM	0.3720 mL	1.8599 mL	3.7199 mL
10 mM	0.1860 mL	0.9300 mL	1.8599 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (275 KB) SDS (251 KB)

COA (256 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Carry JC, et, al. Novel thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof. US20130261106A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8599 mL	9.2997 mL	18.5995 mL	46.4986 mL
	5 mM	0.3720 mL	1.8599 mL	3.7199 mL	9.2997 mL
	10 mM	0.1860 mL	0.9300 mL	1.8599 mL	4.6499 mL
	15 mM	0.1240 mL	0.6200 mL	1.2400 mL	3.0999 mL
	20 mM	0.0930 mL	0.4650 mL	0.9300 mL	2.3249 mL
	25 mM	0.0744 mL	0.3720 mL	0.7440 mL	1.8599 mL
	30 mM	0.0620 mL	0.3100 mL	0.6200 mL	1.5500 mL
	40 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1625 mL
	50 mM	0.0372 mL	0.1860 mL	0.3720 mL	0.9300 mL
	60 mM	0.0310 mL	0.1550 mL	0.3100 mL	0.7750 mL
	80 mM	0.0232 mL	0.1162 mL	0.2325 mL	0.5812 mL
	100 mM	0.0186 mL	0.0930 mL	0.1860 mL	0.4650 mL