Allethrin

Cat. No.: HY-B1559 Purity: 98.04%: FAQs
Data Sheet SDS COA Handling Instructions

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Allethrin, a pyrethroid insecticide is a major mosquito repellent agent. Allethrin induces oxidative stress, apoptosis and calcium release in rat testicular carcinoma cells (LC540). Allethrin induces BCL-2, caspase-3 activation and release of intracellular calcium.

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Allethrin Chemical Structure

CAS No. : 584-79-2

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Description

In Vitro

Allethrin (0.001-250 μM) induces cytotoxicity and oxidative stress. Allethrin is cytotoxic to isolated Leydig cells and testicular cancer cells. Cytotoxicity is due to free radical generation and altered antioxidant status^[1].
Morphological analyses of LC540 cells treated with Allethrin (125 μM) reveals the presence of apoptotic bodies^[1].
Allethrin (125 μM) induces BCL-2, caspase-3 activation and release of intracellular calcium^[1].
Allethrin (IC₅₀≈85 μM) is toxic to human corneal epithelial (HCE) cells causing death through mitochondrial pathway^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:	LC540 cells (derived from rat Leydig cell tumor)
Concentration:	0.001-250 μM
Incubation Time:	24 hours
Result:	At low concentrations did not display appreciable cell killing activity up to 50 μM when incubated for 24 h. At concentrations above 100 μM, cell killing was observed. Based on the results obtained, the IC₅₀ was 125 μM.

Apoptosis Analysis^[1]

Cell Line:	LC540 cells
Concentration:	125 μM
Incubation Time:	24 hours
Result:	Revealed the presence of apoptotic bodies. The percentage of cells displaying early apoptotic features increased significantly.

Western Blot Analysis^[1]

Cell Line:	LC540 cells
Concentration:	125 μM
Incubation Time:	0, 3, 6, 9, 12, 24 hours
Result:	BCL-2, pro-Caspase-3 and PARP-1 protein expression decreased significantly with an increase in cleaved PARP-1 levels.

In Vivo

Adult male rats are treated orally with Allethrin (25, 50, 100, and 150 mg/kg; every day for 60 days). Lipid peroxidation is increased in the caput, cauda, and testes. Nitric oxide production is increased in the caput, but unaltered in the cauda and testes. The activities of catalase, glutathione peroxidase (GPx), glutathione-S-transferase (GST), and superoxide dismutase (SOD) are decreased in the caput and cauda^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats aged 90 days^[3]
Dosage:	25, 50, 100, and 150 mg/kg
Administration:	Orally administered every day for 60 days
Result:	Increased levels of LPO products were observed in the caput, cauda, and testes of allethrin treated rats. In the caput, increased levels of NO was observed at all the doses tested, when compared with the vehicle treated control. Significant increase in catalase activity was observed in the cauda obtained from 50, 100, and 150 mg/kg. GPx activity was significantly increased in the caput obtained from 150 mg/kg treated rats. In the cauda, it was found to be increased significantly in the 50 and 100 mg/kg treated groups. In contrast, the activity of GPx activity was significantly decreased in the testes of rats treated with 150 mg/kg. GST activity was found to be increased significantly in a dose dependent manner in the caput and cauda of allethrin treated rats. In the caput, significant increase in the activity of SOD was observed in the 150 mg/kg body treated rats. In the cauda and testes, treatment resulted in increase of SOD activity at all the doses tested.

Molecular Weight

302.41

Formula

C₁₉H₂₆O₃

CAS No.

584-79-2

Appearance

Liquid (Density: 1.01 g/cm³)

Color

Colorless to light yellow

SMILES

O=C(C1C(C)(C)C1/C=C(C)\C)OC2C(C)=C(CC=C)C(C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (330.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3068 mL	16.5338 mL	33.0677 mL
5 mM	0.6614 mL	3.3068 mL	6.6135 mL
10 mM	0.3307 mL	1.6534 mL	3.3068 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.04%

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Data Sheet (276 KB) SDS (537 KB)

COA (246 KB) HNMR (270 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

References

[1]. Golla Madhubabu, et al. Allethrin induces oxidative stress, apoptosis and calcium release in rat testicular carcinoma cells (LC540). Toxicol In Vitro. 2014 Dec;28(8):1386-95. [Content Brief]

[2]. Geetika Gupta, et al. Allethrin toxicity on human corneal epithelial cells involves mitochondrial pathway mediated apoptosis. Toxicol In Vitro. 2013 Dec;27(8):2242-8. [Content Brief]

[3]. Golla Madhubabu, et al. Allethrin induced toxicity in the male reproductive tract of rats contributes to disruption in the transcription of genes involved in germ cell production. Environ Toxicol. 2014 Nov;29(11):1330-45. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3068 mL	16.5338 mL	33.0677 mL	82.6692 mL
	5 mM	0.6614 mL	3.3068 mL	6.6135 mL	16.5338 mL
	10 mM	0.3307 mL	1.6534 mL	3.3068 mL	8.2669 mL
	15 mM	0.2205 mL	1.1023 mL	2.2045 mL	5.5113 mL
	20 mM	0.1653 mL	0.8267 mL	1.6534 mL	4.1335 mL
	25 mM	0.1323 mL	0.6614 mL	1.3227 mL	3.3068 mL
	30 mM	0.1102 mL	0.5511 mL	1.1023 mL	2.7556 mL
	40 mM	0.0827 mL	0.4133 mL	0.8267 mL	2.0667 mL
	50 mM	0.0661 mL	0.3307 mL	0.6614 mL	1.6534 mL
	60 mM	0.0551 mL	0.2756 mL	0.5511 mL	1.3778 mL
	80 mM	0.0413 mL	0.2067 mL	0.4133 mL	1.0334 mL
	100 mM	0.0331 mL	0.1653 mL	0.3307 mL	0.8267 mL

Allethrin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Allethrin584-79-2ApoptosisPyrethroidinsecticidemosquitorepellentoxidativestressapoptosiscalciumreleaseepididymistestisspermmaturationInhibitorinhibitorinhibit

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