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  6. alpha-Boswellic acid

alpha-Boswellic acid  (Synonyms: α-Boswellic acid)

Cat. No.: HY-N0611 Purity: 99.32%
COA Handling Instructions

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alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

alpha-Boswellic acid Chemical Structure

alpha-Boswellic acid Chemical Structure

CAS No. : 471-66-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 191 In-stock
Solution
10 mM * 1 mL in DMSO USD 191 In-stock
Solid
1 mg USD 61 In-stock
5 mg USD 190 In-stock
10 mg USD 300 In-stock
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100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of alpha-Boswellic acid:

alpha-Boswellic acid Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

alpha-Boswellic acid (α-Boswellic acid) is an orally active pentacyclic triterpenoid compound that can be extracted from frankincense. alpha-Boswellic acid has anti-inflammatory and antitumor activities. alpha-Boswellic acid can be used in Alzheimer's disease (AD) research[1][2][3].

In Vitro

alpha-Boswellic acid (1, 3, 10 μM, 20 min) can reduce the expression levels of cytokines (IL-1β, IL-6 and IL-8) stimulated by TNF-α/IFN-γ in HaCaT cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

alpha-Boswellic acid Related Antibodies

RT-PCR[1]

Cell Line: HaCaT
Concentration: 1, 3, 10 μM
Incubation Time: 20 min
Result: Decreased IL-1β, IL-6, IL-8, MDC, and TARC mRNA expression.
Increased the mRNA expression of involucrin, filaggrin, and loricrin in TNF-α/IFN-γ-induced cells.

Western Blot Analysis[1]

Cell Line: HaCaT
Concentration: 1, 3, 10 μM
Incubation Time: 20 min
Result: Inhibited ERK, p38, and JNK protein phosphorylation.
Reduced the phosphorylated NF-κB protein levels.
In Vivo

alpha-Boswellic acid (3 or 10 mg/kg, intraperitoneal injection) decreases epidermal thickening, mast cell count and dermal infiltration in BALB/c mice induced by 2, 4-dinitrochlorobenzene[1].
alpha-Boswellic acid (200 mg/kg, gavage) has a protective effect on ethanol-induced gastric injury in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 2,4-Dinitrochlorobenzene-Induced Atopic-like Dermatitis in BALB/c Mice[1]
Dosage: 3 or 10 mg/kg
Administration: i.p.
Result: Reduced the severity of the AD-like symptoms.
Attenuated the increase in ear thickness and decreased cutaneous TEWL in DNCB-treated mice.
Animal Model: Ethanol-induced gastric injury in rats[2]
Dosage: 200 mg/kg
Administration: i.g.
Result: Reduced injuries associated with the administration of ethanol, gastric juice acidity and the formation of MDA and increased CAT activity and SOD activity and the level of NO and PGE-2 in a dose-depended manner.
Increased the expression of both Nrf2 and HO-1.
Molecular Weight

456.70

Formula

C30H48O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@@]12C)(CC[C@@]3([H])[C@@]4(C)C(O)=O)[C@@](CC=C1[C@@](CC(C)(C)CC5)([H])[C@@]5(C)CC2)([H])[C@]3(CC[C@H]4O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (54.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1896 mL 10.9481 mL 21.8962 mL
5 mM 0.4379 mL 2.1896 mL 4.3792 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (5.47 mM); Suspended solution; Need ultrasonic

    This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.32%

COA (250 KB) HNMR (263 KB) RP-HPLC (207 KB) MS (70 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1896 mL 10.9481 mL 21.8962 mL 54.7405 mL
5 mM 0.4379 mL 2.1896 mL 4.3792 mL 10.9481 mL
10 mM 0.2190 mL 1.0948 mL 2.1896 mL 5.4741 mL
15 mM 0.1460 mL 0.7299 mL 1.4597 mL 3.6494 mL
20 mM 0.1095 mL 0.5474 mL 1.0948 mL 2.7370 mL
25 mM 0.0876 mL 0.4379 mL 0.8758 mL 2.1896 mL
30 mM 0.0730 mL 0.3649 mL 0.7299 mL 1.8247 mL
40 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3685 mL
50 mM 0.0438 mL 0.2190 mL 0.4379 mL 1.0948 mL
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alpha-Boswellic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

alpha-Boswellic acid471-66-9α-Boswellic acidOthersAnti-inflammatoryAntitumorHaCaTEthanol-induced gastric injuryInhibitorinhibitorinhibit

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