2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. AMG-Tie2-1

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM.

For research use only. We do not sell to patients.

AMG-Tie2-1 Chemical Structure

AMG-Tie2-1 Chemical Structure

CAS No. : 870223-96-4

Size Price Stock Quantity
1 mg USD 55 In-stock
5 mg USD 220 In-stock
10 mg USD 380 In-stock
25 mg USD 760 In-stock
50 mg USD 1220 In-stock
100 mg USD 1950 In-stock
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Based on 1 publication(s) in Google Scholar

AMG-Tie2-1 Related Antibodies

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) with an IC50 of 1 nM. AMG-Tie2-1 is a VEGFR2 inhibitor with an IC50 of 3 nM[1].

In Vitro

AMG-Tie2-1 (compound 15) inhibits Tie-2 phosphorylation in EA.hy926 human endothelial cells (IC50=10 nM).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AMG-Tie2-1 Related Antibodies
Molecular Weight

479.45

Formula

C25H20F3N5O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CNC1=NC(C2=CC=CN=C2OC3=C(C)C=CC(C(NC4=CC=CC(C(F)(F)F)=C4)=O)=C3)=CC=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (365.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0857 mL 10.4286 mL 20.8572 mL
5 mM 0.4171 mL 2.0857 mL 4.1714 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.5%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0857 mL 10.4286 mL 20.8572 mL 52.1431 mL
5 mM 0.4171 mL 2.0857 mL 4.1714 mL 10.4286 mL
10 mM 0.2086 mL 1.0429 mL 2.0857 mL 5.2143 mL
15 mM 0.1390 mL 0.6952 mL 1.3905 mL 3.4762 mL
20 mM 0.1043 mL 0.5214 mL 1.0429 mL 2.6072 mL
25 mM 0.0834 mL 0.4171 mL 0.8343 mL 2.0857 mL
30 mM 0.0695 mL 0.3476 mL 0.6952 mL 1.7381 mL
40 mM 0.0521 mL 0.2607 mL 0.5214 mL 1.3036 mL
50 mM 0.0417 mL 0.2086 mL 0.4171 mL 1.0429 mL
60 mM 0.0348 mL 0.1738 mL 0.3476 mL 0.8691 mL
80 mM 0.0261 mL 0.1304 mL 0.2607 mL 0.6518 mL
100 mM 0.0209 mL 0.1043 mL 0.2086 mL 0.5214 mL
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AMG-Tie2-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-Tie2-1870223-96-4VEGFRVascular endothelial growth factor receptorInhibitorinhibitorinhibit

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