Aminomalonic acid

Name: Aminomalonic acid
Brand: MedChemExpress
SKU: HY-112052
Rating: 4.5 (1 reviews)

Cat. No.: HY-112052 Purity: 98.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (K_i= 0.0023 M) and mouse pancreas (K_i= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis.

For research use only. We do not sell to patients.

Aminomalonic acid Chemical Structure

CAS No. : 1068-84-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 32	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

119.08

Formula

C₃H₅NO₄

CAS No.

1068-84-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(N)C(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 8.33 mg/mL (69.95 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.3977 mL	41.9886 mL	83.9772 mL
5 mM	1.6795 mL	8.3977 mL	16.7954 mL
10 mM	0.8398 mL	4.1989 mL	8.3977 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 5 mg/mL (41.99 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.87%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (246 KB) HNMR (129 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. Van Buskirk JJ, et al. Aminomalonic acid: identification in Escherichia coli and atherosclerotic plaque. Proc Natl Acad Sci U S A. 1984 Feb;81(3):722-5. [Content Brief]

[2]. Milman HA, et al. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase. Enzyme. 1979;24(1):36-47. [Content Brief]

[3]. Kim HY, et al. Discovery of potential biomarkers in human melanoma cells with different metastatic potential by metabolic and lipidomic profiling. Sci Rep. 2017 Aug 18;7(1):8864. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	8.3977 mL	41.9886 mL	83.9772 mL	209.9429 mL
	5 mM	1.6795 mL	8.3977 mL	16.7954 mL	41.9886 mL
	10 mM	0.8398 mL	4.1989 mL	8.3977 mL	20.9943 mL
	15 mM	0.5598 mL	2.7992 mL	5.5985 mL	13.9962 mL
	20 mM	0.4199 mL	2.0994 mL	4.1989 mL	10.4971 mL
	25 mM	0.3359 mL	1.6795 mL	3.3591 mL	8.3977 mL
	30 mM	0.2799 mL	1.3996 mL	2.7992 mL	6.9981 mL
	40 mM	0.2099 mL	1.0497 mL	2.0994 mL	5.2486 mL
	50 mM	0.1680 mL	0.8398 mL	1.6795 mL	4.1989 mL
	60 mM	0.1400 mL	0.6998 mL	1.3996 mL	3.4990 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.