2. MAPK/ERK Pathway
  3. p38 MAPK
  4. Andrograpanin

Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties.

For research use only. We do not sell to patients.

Andrograpanin Chemical Structure

Andrograpanin Chemical Structure

CAS No. : 82209-74-3

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10 mg USD 250 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Andrograpanin:

Andrograpanin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Andrograpanin

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties[1][2].

Cellular Effect
Cell Line Type Value Description References
HL-60 GI50
20.01 μM
Compound: 6
Antiproliferative activity against human HL60 cells by trypan blue assay
Antiproliferative activity against human HL60 cells by trypan blue assay
[PMID: 18357994]
RAW264.7 IC50
11.6 μM
Compound: 25
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
[PMID: 22264489]
In Vitro

Andrograpanin exhibits anti-inflammatory properties in lipopolysaccharide-induced macrophage cells through down-regulating the p38 MAPKs signaling pathways[1].
Andrograpanin enhances chemokine SDF-1α-induced leukocytes chemotaxis in Jurkat, THP-1 and PBL cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Andrograpanin Related Antibodies
Molecular Weight

318.45

Formula

C20H30O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1OCC=C1CC[C@@H]2C(CC[C@]3([H])[C@](C)(CO)CCC[C@@]23C)=C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (314.02 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1402 mL 15.7011 mL 31.4021 mL
5 mM 0.6280 mL 3.1402 mL 6.2804 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

SDS (393 KB)

COA (252 KB) HNMR (268 KB) LCMS (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1402 mL 15.7011 mL 31.4021 mL 78.5053 mL
5 mM 0.6280 mL 3.1402 mL 6.2804 mL 15.7011 mL
10 mM 0.3140 mL 1.5701 mL 3.1402 mL 7.8505 mL
15 mM 0.2093 mL 1.0467 mL 2.0935 mL 5.2337 mL
20 mM 0.1570 mL 0.7851 mL 1.5701 mL 3.9253 mL
25 mM 0.1256 mL 0.6280 mL 1.2561 mL 3.1402 mL
30 mM 0.1047 mL 0.5234 mL 1.0467 mL 2.6168 mL
40 mM 0.0785 mL 0.3925 mL 0.7851 mL 1.9626 mL
50 mM 0.0628 mL 0.3140 mL 0.6280 mL 1.5701 mL
60 mM 0.0523 mL 0.2617 mL 0.5234 mL 1.3084 mL
80 mM 0.0393 mL 0.1963 mL 0.3925 mL 0.9813 mL
100 mM 0.0314 mL 0.1570 mL 0.3140 mL 0.7851 mL
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Andrograpanin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Andrograpanin82209-74-3p38 MAPKanti-inflammatorySDF-1αJurkatTHP-1PBLleukocytechemotaxisInhibitorinhibitorinhibit

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