Anti-inflammatory agent 70

Cat. No.: HY-157570 Purity: 97.00%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Anti-inflammatory agent 70 (N-Me-SP23) is a STING protein PROTAC degrader and inhibits the STING signaling pathway. Anti-inflammatory agent 70 has anti-inflammatory activity. (Pink: STING inhibitor (HY-47709); Black: linker (HY-W008296); Blue: CRBN Ligand (HY-W460193)).

For research use only. We do not sell to patients.

Anti-inflammatory agent 70 Chemical Structure

CAS No. : 2767427-87-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 736	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 736	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 469	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 751	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1502	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2403	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3846	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

713.69

Formula

C₃₅H₃₅N₇O₁₀

CAS No.

2767427-87-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

[O-][N+](C1=CC=C(C(NC2=CC=C(NC(/C=C/C(NCCCCCCNC3=C4C(C(N(C4=O)C5CCC(N(C5=O)C)=O)=O)=CC=C3)=O)=O)C=C2)=O)O1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (140.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4012 mL	7.0058 mL	14.0117 mL
5 mM	0.2802 mL	1.4012 mL	2.8023 mL
10 mM	0.1401 mL	0.7006 mL	1.4012 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.00%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (172 KB) RP-HPLC (226 KB) LCMS (404 KB)

Handling Instructions (2659 KB)

References

[1]. Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65(9):6593-6611. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.4012 mL	7.0058 mL	14.0117 mL	35.0292 mL
	5 mM	0.2802 mL	1.4012 mL	2.8023 mL	7.0058 mL
	10 mM	0.1401 mL	0.7006 mL	1.4012 mL	3.5029 mL
	15 mM	0.0934 mL	0.4671 mL	0.9341 mL	2.3353 mL
	20 mM	0.0701 mL	0.3503 mL	0.7006 mL	1.7515 mL
	25 mM	0.0560 mL	0.2802 mL	0.5605 mL	1.4012 mL
	30 mM	0.0467 mL	0.2335 mL	0.4671 mL	1.1676 mL
	40 mM	0.0350 mL	0.1751 mL	0.3503 mL	0.8757 mL
	50 mM	0.0280 mL	0.1401 mL	0.2802 mL	0.7006 mL
	60 mM	0.0234 mL	0.1168 mL	0.2335 mL	0.5838 mL
	80 mM	0.0175 mL	0.0876 mL	0.1751 mL	0.4379 mL
	100 mM	0.0140 mL	0.0701 mL	0.1401 mL	0.3503 mL