2. PROTAC
  3. Ligands for E3 Ligase
  4. N-Me-Thalidomide 4-fluoride

N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570).

For research use only. We do not sell to patients.

N-Me-Thalidomide 4-fluoride Chemical Structure

N-Me-Thalidomide 4-fluoride Chemical Structure

CAS No. : 2244520-92-9

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Based on 1 publication(s) in Google Scholar

N-Me-Thalidomide 4-fluoride Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570)[1].

IC50 & Target

Cereblon

 

Molecular Weight

290.25

Formula

C14H11FN2O4
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C1C2=C(C(N1C3C(N(C)C(CC3)=O)=O)=O)C(F)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (57.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4453 mL 17.2265 mL 34.4531 mL
5 mM 0.6891 mL 3.4453 mL 6.8906 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

COA (252 KB) HNMR (120 KB) RP-HPLC (192 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4453 mL 17.2265 mL 34.4531 mL 86.1326 mL
5 mM 0.6891 mL 3.4453 mL 6.8906 mL 17.2265 mL
10 mM 0.3445 mL 1.7227 mL 3.4453 mL 8.6133 mL
15 mM 0.2297 mL 1.1484 mL 2.2969 mL 5.7422 mL
20 mM 0.1723 mL 0.8613 mL 1.7227 mL 4.3066 mL
25 mM 0.1378 mL 0.6891 mL 1.3781 mL 3.4453 mL
30 mM 0.1148 mL 0.5742 mL 1.1484 mL 2.8711 mL
40 mM 0.0861 mL 0.4307 mL 0.8613 mL 2.1533 mL
50 mM 0.0689 mL 0.3445 mL 0.6891 mL 1.7227 mL
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N-Me-Thalidomide 4-fluoride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Me-Thalidomide 4-fluoride2244520-92-9Ligands for E3 LigaseE3 ligase-recruiting MoietySTINGInhibitorinhibitorinhibit

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