Apalutamide-COOH

Cat. No.: HY-136596 Purity: 99.14%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC₅₀ of 16 nM.

For research use only. We do not sell to patients.

Apalutamide-COOH Chemical Structure

CAS No. : 1332391-04-4

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Apalutamide-COOH is a metabolite of Apalutamide. Apalutamide is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC₅₀ of 16 nM^[1].

Molecular Weight

464.39

Formula

C₂₀H₁₂F₄N₄O₃S

CAS No.

1332391-04-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (269.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1534 mL	10.7668 mL	21.5336 mL
5 mM	0.4307 mL	2.1534 mL	4.3067 mL
10 mM	0.2153 mL	1.0767 mL	2.1534 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.14%

Select Batch:

Data Sheet (270 KB) SDS (643 KB)

COA (253 KB) HNMR (258 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Nicholas D. Smith, et al. Androgen receptor modulators and uses thereof. WO2011103202A2.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1534 mL	10.7668 mL	21.5336 mL	53.8341 mL
	5 mM	0.4307 mL	2.1534 mL	4.3067 mL	10.7668 mL
	10 mM	0.2153 mL	1.0767 mL	2.1534 mL	5.3834 mL
	15 mM	0.1436 mL	0.7178 mL	1.4356 mL	3.5889 mL
	20 mM	0.1077 mL	0.5383 mL	1.0767 mL	2.6917 mL
	25 mM	0.0861 mL	0.4307 mL	0.8613 mL	2.1534 mL
	30 mM	0.0718 mL	0.3589 mL	0.7178 mL	1.7945 mL
	40 mM	0.0538 mL	0.2692 mL	0.5383 mL	1.3459 mL
	50 mM	0.0431 mL	0.2153 mL	0.4307 mL	1.0767 mL
	60 mM	0.0359 mL	0.1794 mL	0.3589 mL	0.8972 mL
	80 mM	0.0269 mL	0.1346 mL	0.2692 mL	0.6729 mL
	100 mM	0.0215 mL	0.1077 mL	0.2153 mL	0.5383 mL