2. GPCR/G Protein
  3. P2Y Receptor
  4. AR-C118925XX

AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth.

For research use only. We do not sell to patients.

AR-C118925XX Chemical Structure

AR-C118925XX Chemical Structure

CAS No. : 216657-60-2

Size Price Stock Quantity
1 mg USD 185 In-stock
5 mg USD 370 In-stock
10 mg USD 592 In-stock
25 mg USD 1180 In-stock
50 mg USD 1888 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

AR-C118925XX Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE AR-C118925XX

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P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

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Description

AR-C118925XX is a selective P2Y2 receptor antagonist. AR-C118925XX inhibits ATP-induced IL-6 production and phosphorylation of p38. AR-C118925XX also inhibits Bleomycin (HY-108345)-induced dermal fibrosis in mice. AR-C118925XX also inhibits ATP-induced tumor growth[1][2].

IC50 & Target[1]

P2Y2 Receptor

 

In Vivo

AR-C118925XX (i.p.) suppresses Bleomycin-enhanced dermal thickness in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

537.59

Formula

C28H23N7O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(CN2C=C(C3C4=CC=C(C)C=C4C=CC5=CC(C)=CC=C53)C(NC2=O)=S)O1)NC6=NN=NN6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (186.02 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8602 mL 9.3008 mL 18.6015 mL
5 mM 0.3720 mL 1.8602 mL 3.7203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥99.0%

COA (254 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8602 mL 9.3008 mL 18.6015 mL 46.5038 mL
5 mM 0.3720 mL 1.8602 mL 3.7203 mL 9.3008 mL
10 mM 0.1860 mL 0.9301 mL 1.8602 mL 4.6504 mL
15 mM 0.1240 mL 0.6201 mL 1.2401 mL 3.1003 mL
20 mM 0.0930 mL 0.4650 mL 0.9301 mL 2.3252 mL
25 mM 0.0744 mL 0.3720 mL 0.7441 mL 1.8602 mL
30 mM 0.0620 mL 0.3100 mL 0.6201 mL 1.5501 mL
40 mM 0.0465 mL 0.2325 mL 0.4650 mL 1.1626 mL
50 mM 0.0372 mL 0.1860 mL 0.3720 mL 0.9301 mL
60 mM 0.0310 mL 0.1550 mL 0.3100 mL 0.7751 mL
80 mM 0.0233 mL 0.1163 mL 0.2325 mL 0.5813 mL
100 mM 0.0186 mL 0.0930 mL 0.1860 mL 0.4650 mL
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AR-C118925XX Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR-C118925XX216657-60-2P2Y ReceptorInhibitorinhibitorinhibit

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HY-110126
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