2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Arimoclomol citrate

Arimoclomol citrate  (Synonyms: BRX-220 citrate)

Cat. No.: HY-106443B Purity: 99.76%
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Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system. Arimoclomol citrate can be used for the study of Niemann–Pick disease type C.

For research use only. We do not sell to patients.

Arimoclomol citrate Chemical Structure

Arimoclomol citrate Chemical Structure

CAS No. : 368860-21-3

Size Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Solid
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Other Forms of Arimoclomol citrate:

Arimoclomol citrate Related Antibodies

Top Publications Citing Use of Products

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • Biological Activity

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Description

Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP)[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2]. Arimoclomol citrate can be used for the study of Niemann–Pick disease type C.

IC50 & Target[1]

HSP

 

In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 240 to 270 g[1]
Dosage: 20 mg/kg
Administration: Administered intragastrically, for 5 days
Result: Had a protective effect against CCK-induced acute pancreatitis.
Clinical Trial
Molecular Weight

505.90

Formula

C20H28ClN3O10
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2.O=C(CC(C(O)=O)(O)CC(O)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 35 mg/mL (69.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9767 mL 9.8834 mL 19.7668 mL
5 mM 0.3953 mL 1.9767 mL 3.9534 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9767 mL 9.8834 mL 19.7668 mL 49.4169 mL
5 mM 0.3953 mL 1.9767 mL 3.9534 mL 9.8834 mL
10 mM 0.1977 mL 0.9883 mL 1.9767 mL 4.9417 mL
15 mM 0.1318 mL 0.6589 mL 1.3178 mL 3.2945 mL
20 mM 0.0988 mL 0.4942 mL 0.9883 mL 2.4708 mL
25 mM 0.0791 mL 0.3953 mL 0.7907 mL 1.9767 mL
30 mM 0.0659 mL 0.3294 mL 0.6589 mL 1.6472 mL
40 mM 0.0494 mL 0.2471 mL 0.4942 mL 1.2354 mL
50 mM 0.0395 mL 0.1977 mL 0.3953 mL 0.9883 mL
60 mM 0.0329 mL 0.1647 mL 0.3294 mL 0.8236 mL
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Arimoclomol citrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arimoclomol368860-21-3BRX-220BRX220BRX 220HSPHeat shock proteinsco-inducermotorneuronsproteinaggregationclearancemisfoldedassembliesproteasomeubiquitinsystemInhibitorinhibitorinhibit

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