Arimoclomol (Synonyms: BRX-220 free base)

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Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol can be used for the study of Niemann–Pick disease type C.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Arimoclomol maleate) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Arimoclomol Chemical Structure

CAS No. : 289893-25-0

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Other Forms of Arimoclomol:

Arimoclomol maleate Get quote
Arimoclomol citrate Get quote

3 Publications Citing Use of MCE Arimoclomol

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Description

Arimoclomol (BRX-220 free base) is an orally active co-inducer of heat shock proteins (HSP)^[1]. Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system^[2].Arimoclomol can be used for the study of Niemann–Pick disease type C.

IC₅₀ & Target^[1]

HSP

In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 240 to 270 g^[1]
Dosage:	20 mg/kg
Administration:	Administered intragastrically, for 5 days
Result:	Had a protective effect against CCK-induced acute pancreatitis.

Clinical Trial

Molecular Weight

313.78

Formula

C₁₄H₂₀ClN₃O₃

CAS No.

289893-25-0

SMILES

Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [Content Brief]

[2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. [Content Brief]

Arimoclomol Related Classifications

Neurological Disease Metabolic Disease Inflammation/Immunology

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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