2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. Aurora kinase inhibitor-8

Aurora kinase inhibitor-8 is a highly selective inhibitor of the Aurora kinases.

For research use only. We do not sell to patients.

Aurora kinase inhibitor-8 Chemical Structure

Aurora kinase inhibitor-8 Chemical Structure

CAS No. : 2133001-88-2

Size Price Stock Quantity
5 mg USD 480 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2600 In-stock
100 mg USD 4000 In-stock
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

Aurora kinase inhibitor-8 Related Antibodies

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Aurora Kinase Aurora A Aurora B Aurora C

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Aurora kinase inhibitor-8 is a highly selective inhibitor of the Aurora kinases.

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.01012 μM
Compound: 2; FMF-03-145-1
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
HEK293 IC50
0.253 μM
Compound: 2; FMF-03-145-1
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
HeLa IC50
1.322 x 10-6 μM
Compound: 2; FMF-03-145-1
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
PC-3 IC50
0.9882 μM
Compound: 2; FMF-03-145-1
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo assay
[PMID: 28818446]
Molecular Weight

535.60

Formula

C30H29N7O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NC1=CC=C(NC2=NC=C(N3C)C(N(C)C4=CC=C(C)C=C4C3=O)=N2)C=C1)C5=CC=C(NC(CC)=O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (46.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8671 mL 9.3353 mL 18.6707 mL
5 mM 0.3734 mL 1.8671 mL 3.7341 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (2.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.25 mg/mL (2.33 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8671 mL 9.3353 mL 18.6707 mL 46.6766 mL
5 mM 0.3734 mL 1.8671 mL 3.7341 mL 9.3353 mL
10 mM 0.1867 mL 0.9335 mL 1.8671 mL 4.6677 mL
15 mM 0.1245 mL 0.6224 mL 1.2447 mL 3.1118 mL
20 mM 0.0934 mL 0.4668 mL 0.9335 mL 2.3338 mL
25 mM 0.0747 mL 0.3734 mL 0.7468 mL 1.8671 mL
30 mM 0.0622 mL 0.3112 mL 0.6224 mL 1.5559 mL
40 mM 0.0467 mL 0.2334 mL 0.4668 mL 1.1669 mL
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Aurora kinase inhibitor-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurora kinase inhibitor-82133001-88-2Aurora kinase inhibitor8Aurora kinase inhibitor 8Aurora KinaseInhibitorinhibitorinhibit

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