Bepridil hydrochloride hydrate (Synonyms: (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate)

Name: Bepridil hydrochloride hydrate
Brand: MedChemExpress
SKU: HY-16952A
Rating: 5.0 (5 reviews)

Cat. No.: HY-16952A Purity: 99.69%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca⁺ channel antagonist and Na⁺, K⁺ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na⁺/Ca2⁺ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders.

For research use only. We do not sell to patients.

Bepridil hydrochloride hydrate Chemical Structure

CAS No. : 74764-40-2

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 28	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of Bepridil hydrochloride hydrate:

Bepridil hydrochloride In-stock
Bepridil Get quote

5 Publications Citing Use of MCE Bepridil hydrochloride hydrate

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View All Calcium Channel Isoform Specific Products:

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Bepridil hydrochloride hydrate blockades of Ca²⁺-dependent action potentials in vascular smooth muscle of dog coronary artery^[2].
? Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC₅₀s of 0.5 μM and 30 μM, respectively in cultured ventricular cells^[4].
? Bepridil hydrochloride hydrate decreases I_Ks under blockade of I_Kr with E4031 (5 μM), in a concentration-dependent manner^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

421.02

Formula

C₂₄H₃₇ClN₂O₂

CAS No.

74764-40-2

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3.[H]Cl.[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (296.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3752 mL	11.8759 mL	23.7518 mL
5 mM	0.4750 mL	2.3752 mL	4.7504 mL
10 mM	0.2375 mL	1.1876 mL	2.3752 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (278 KB) SDS (252 KB)

COA (252 KB) HNMR (283 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. A Gill, et al. Pharmacology of Bepridil. Am J Cardiol. 1992 Apr 9;69(11):11D-16D. [Content Brief]

[2]. D R Harder, et al. Bepridil Blockade of Ca2+-dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery. J Cardiovasc Pharmacol. Jul-Aug 1981;3(4):906-14. [Content Brief]

[3]. Yasuhide Watanabe. Cardiac Na +/Ca 2+ Exchange Stimulators Among Cardioprotective Drugs. J Physiol Sci. 2019 Nov;69(6):837-849. [Content Brief]

[4]. A Yatani, et al. Bepridil Block of Cardiac Calcium and Sodium Channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17. [Content Brief]

[5]. J C Wang, et al. Bepridil Differentially Inhibits Two Delayed Rectifier K(+) Currents, I(Kr) and I(Ks), in Guinea-Pig Ventricular Myocytes. Br J Pharmacol. 1999 Dec;128(8):1733-8. [Content Brief]

[6]. L Z Benet, et al. Pharmacokinetics and Metabolism of Bepridil. Am J Cardiol. 1985 Mar 15;55(7):8C-13C. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3752 mL	11.8759 mL	23.7518 mL	59.3796 mL
	5 mM	0.4750 mL	2.3752 mL	4.7504 mL	11.8759 mL
	10 mM	0.2375 mL	1.1876 mL	2.3752 mL	5.9380 mL
	15 mM	0.1583 mL	0.7917 mL	1.5835 mL	3.9586 mL
	20 mM	0.1188 mL	0.5938 mL	1.1876 mL	2.9690 mL
	25 mM	0.0950 mL	0.4750 mL	0.9501 mL	2.3752 mL
	30 mM	0.0792 mL	0.3959 mL	0.7917 mL	1.9793 mL
	40 mM	0.0594 mL	0.2969 mL	0.5938 mL	1.4845 mL
	50 mM	0.0475 mL	0.2375 mL	0.4750 mL	1.1876 mL
	60 mM	0.0396 mL	0.1979 mL	0.3959 mL	0.9897 mL
	80 mM	0.0297 mL	0.1484 mL	0.2969 mL	0.7422 mL
	100 mM	0.0238 mL	0.1188 mL	0.2375 mL	0.5938 mL

Bepridil hydrochloride hydrate Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bepridil hydrochloride74764-40-2(±)-Bepridil hydrochlorideOrg 5730 hydrochlorideCalcium ChannelCa2+ channelsCa channelscalciumsodiumpotassiumchannelantianginalantiarrhythmiccardiovasculardisordersInhibitorinhibitorinhibit

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Bepridil hydrochloride hydrate (Synonyms: (±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate)

Customer Review

Other Forms of Bepridil hydrochloride hydrate:

Bepridil hydrochloride hydrate Related Antibodies

5 Publications Citing Use of MCE Bepridil hydrochloride hydrate

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Calcium Channel Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Bepridil hydrochloride hydrate Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Bepridil hydrochloride hydrate Related Classifications

Keywords:

Your Recently Viewed Products:

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