BET bromodomain inhibitor 3

Name: BET bromodomain inhibitor 3
Brand: MedChemExpress
SKU: HY-153593
Rating: 4.5 (1 reviews)

Cat. No.: HY-153593 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

BET bromodomain inhibitor 3 is BET bromodomain inhibitor. BET bromodomain inhibitor 3 has inhibitory effect against BrdT with K_i value of > 40 µM. BET bromodomain inhibitor 3 can be used for the research of contraception, cancer, and heart disease.

For research use only. We do not sell to patients.

BET bromodomain inhibitor 3 Chemical Structure

CAS No. : 854137-39-6

Size	Price	Stock	Quantity
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Ki: > 40 µM (BrdT)^[1]

In Vitro

BET bromodomain inhibitor 3 has inhibitory effect against BrdT with K_i value of > 40 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

339.35

Formula

C₁₈H₁₇N₃O₄

CAS No.

854137-39-6

Appearance

Solid

Color

White to off-white

SMILES

O=C1OCC2=C1C(C3=CC=C(C)C=C3)C(C(N(C)C(N4C)=O)=O)=C4N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (147.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9468 mL	14.7340 mL	29.4681 mL
5 mM	0.5894 mL	2.9468 mL	5.8936 mL
10 mM	0.2947 mL	1.4734 mL	2.9468 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (256 KB) HNMR (215 KB)

Handling Instructions (2659 KB)

References

[1]. Ayoub AM, et al. BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen [published correction appears in J Med Chem. 2017 Jul 27;60(14):6458]. J Med Chem. 2017;60(12):4805-4817. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9468 mL	14.7341 mL	29.4681 mL	73.6703 mL
	5 mM	0.5894 mL	2.9468 mL	5.8936 mL	14.7341 mL
	10 mM	0.2947 mL	1.4734 mL	2.9468 mL	7.3670 mL
	15 mM	0.1965 mL	0.9823 mL	1.9645 mL	4.9114 mL
	20 mM	0.1473 mL	0.7367 mL	1.4734 mL	3.6835 mL
	25 mM	0.1179 mL	0.5894 mL	1.1787 mL	2.9468 mL
	30 mM	0.0982 mL	0.4911 mL	0.9823 mL	2.4557 mL
	40 mM	0.0737 mL	0.3684 mL	0.7367 mL	1.8418 mL
	50 mM	0.0589 mL	0.2947 mL	0.5894 mL	1.4734 mL
	60 mM	0.0491 mL	0.2456 mL	0.4911 mL	1.2278 mL
	80 mM	0.0368 mL	0.1842 mL	0.3684 mL	0.9209 mL
	100 mM	0.0295 mL	0.1473 mL	0.2947 mL	0.7367 mL