2. Neuronal Signaling
  3. Amyloid-β
  4. β-Amyrin

β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD.

For research use only. We do not sell to patients.

β-Amyrin Chemical Structure

β-Amyrin Chemical Structure

CAS No. : 559-70-6

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1 mg USD 100 In-stock
5 mg USD 250 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of β-Amyrin:

β-Amyrin Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Amyrin, an ingredient of Celastrus hindsii, blocks amyloid β (Aβ)-induced long-term potentiation (LTP) impairment. β-amyrin is a promising candidate of treatment for AD[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
23.55 μM
Compound: 10
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
B16 ED50
> 50 μM
Compound: 14
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
Induction of melanogenesis in mouse B16 2F2 cells assessed as intracellular melanin content after 3 days
[PMID: 12027734]
B16 IC50
48.8 μM
Compound: 14
Growth inhibition of mouse B16 2F2 cells after 3 days
Growth inhibition of mouse B16 2F2 cells after 3 days
[PMID: 12027734]
DU-145 IC50
27.88 μM
Compound: 10
Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
HEK293 IC50
94.4 μM
Compound: 10
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
HeLa IC50
> 50 μM
Compound: 4
Cytotoxicity against human HeLa cells by MTT assay
Cytotoxicity against human HeLa cells by MTT assay
[PMID: 19447618]
HeLa IC50
27.94 μM
Compound: 10
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
J774 IC50
> 234.3 μM
Compound: 2
Cytotoxicity against mouse J774 cells by alamar blue assay
Cytotoxicity against mouse J774 cells by alamar blue assay
[PMID: 17637068]
MCF7 IC50
> 50 μM
Compound: 4
Cytotoxicity against human MCF7 cells by MTT assay
Cytotoxicity against human MCF7 cells by MTT assay
[PMID: 19447618]
MCF7 IC50
35.31 μM
Compound: 10
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 28482219]
SK-MEL-1 IC50
> 50 μM
Compound: 4
Cytotoxicity against human SK-MEL-1 cells by MTT assay
Cytotoxicity against human SK-MEL-1 cells by MTT assay
[PMID: 19447618]
Molecular Weight

426.72

Formula

C30H50O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (23.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3435 mL 11.7173 mL 23.4346 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.58%

SDS (393 KB)

COA (253 KB) HNMR (273 KB) RP-HPLC (217 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.3435 mL 11.7173 mL 23.4346 mL 58.5864 mL
5 mM 0.4687 mL 2.3435 mL 4.6869 mL 11.7173 mL
10 mM 0.2343 mL 1.1717 mL 2.3435 mL 5.8586 mL
15 mM 0.1562 mL 0.7812 mL 1.5623 mL 3.9058 mL
20 mM 0.1172 mL 0.5859 mL 1.1717 mL 2.9293 mL
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β-Amyrin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Amyrin559-70-6Amyloid-ββ-amyloid peptideAβAbetaInhibitorinhibitorinhibit

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