Brimonidine-d₄ D-tartrate

Name: Brimonidine-d 4 D-tartrate
Brand: MedChemExpress
SKU: HY-B0659AS
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0659AS Purity: ≥99.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Brimonidine-d₄ (D-tartrate) is the deuterium labeled Brimonidine D-tartrate[1].

For research use only. We do not sell to patients.

Brimonidine-d<sub>4</sub> D-tartrate Chemical Structure

Brimonidine-d₄ D-tartrate Chemical Structure

CAS No. : 1316758-27-6

Size	Price	Stock	Quantity
1 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1450	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Brimonidine-d₄ D-tartrate:

Brimonidine tartrate In-stock
Brimonidine-d₄ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Brimonidine-d₄ (D-tartrate) is the deuterium labeled Brimonidine D-tartrate[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

446.25

Formula

C₁₅H₁₂D₄BrN₅O₆

CAS No.

1316758-27-6

Unlabeled CAS

1350706-20-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

OC([C@@H](O)[C@H](O)C(O)=O)=O.BrC1=C(NC2=NC([2H])([2H])C([2H])([2H])N2)C=CC3=C1N=CC=N3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (112.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 25 mg/mL (56.02 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2409 mL	11.2045 mL	22.4090 mL
5 mM	0.4482 mL	2.2409 mL	4.4818 mL
10 mM	0.2241 mL	1.1204 mL	2.2409 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (261 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / H₂O / DMSO	1 mM	2.2409 mL	11.2045 mL	22.4090 mL	56.0224 mL
	5 mM	0.4482 mL	2.2409 mL	4.4818 mL	11.2045 mL
	10 mM	0.2241 mL	1.1204 mL	2.2409 mL	5.6022 mL
	15 mM	0.1494 mL	0.7470 mL	1.4939 mL	3.7348 mL
	20 mM	0.1120 mL	0.5602 mL	1.1204 mL	2.8011 mL
	25 mM	0.0896 mL	0.4482 mL	0.8964 mL	2.2409 mL
	30 mM	0.0747 mL	0.3735 mL	0.7470 mL	1.8674 mL
	40 mM	0.0560 mL	0.2801 mL	0.5602 mL	1.4006 mL
	50 mM	0.0448 mL	0.2241 mL	0.4482 mL	1.1204 mL
DMSO	60 mM	0.0373 mL	0.1867 mL	0.3735 mL	0.9337 mL
	80 mM	0.0280 mL	0.1401 mL	0.2801 mL	0.7003 mL
	100 mM	0.0224 mL	0.1120 mL	0.2241 mL	0.5602 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.