Bufuralol hydrochloride (Synonyms: Ro 3-4787 hydrochloride)

Name: Bufuralol hydrochloride
Brand: MedChemExpress
SKU: HY-105124A
Rating: 4.5 (1 reviews)

Cat. No.: HY-105124A Purity: 98.01%: FAQs
Data Sheet SDS COA Handling Instructions

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Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.

For research use only. We do not sell to patients.

Bufuralol hydrochloride Chemical Structure

CAS No. : 60398-91-6

Size	Price	Stock	Quantity
1 mg	USD 101	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 690	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2400	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 3850	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Bufuralol hydrochloride:

Bufuralol Get quote

1 Publications Citing Use of MCE Bufuralol hydrochloride

•J Pharmaceut Biomed. 2020, 113870.

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate^[1]^[2].

IC₅₀ & Target^[1]

β adrenergic receptor

In Vitro

Bufuralol (Ro 3-4787) hydrochloride is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bufuralol (Ro 3-4787) hydrochloride metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

297.82

Formula

C₁₆H₂₄ClNO₂

CAS No.

60398-91-6

Appearance

Solid

Color

Off-white to light brown

SMILES

OC(CNC(C)(C)C)C1=CC2=CC=CC(CC)=C2O1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

Ethanol : 15 mg/mL (50.37 mM; Need ultrasonic and warming)

DMSO : 10 mg/mL (33.58 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3577 mL	16.7887 mL	33.5773 mL
5 mM	0.6715 mL	3.3577 mL	6.7155 mL
10 mM	0.3358 mL	1.6789 mL	3.3577 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥99.0%

Select Batch:

Data Sheet (276 KB) SDS (252 KB)

COA (250 KB)

Handling Instructions (2659 KB)

References

[1]. T H Pringle, et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br J Clin Pharmacol. 1986 Nov;22(5):527-34. [Content Brief]

[2]. Jie Cai, et al. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):190-9. [Content Brief]

[3]. Sarah M Glass, et al. CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. Drug Metab Dispos. 2018 Aug;46(8):1106-1117. [Content Brief]

[4]. T Prueksaritanont, et al. (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver. Biochem Pharmacol. 1995 Oct 26;50(9):1521-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / Ethanol	1 mM	3.3577 mL	16.7887 mL	33.5773 mL	83.9433 mL
	5 mM	0.6715 mL	3.3577 mL	6.7155 mL	16.7887 mL
	10 mM	0.3358 mL	1.6789 mL	3.3577 mL	8.3943 mL
	15 mM	0.2238 mL	1.1192 mL	2.2385 mL	5.5962 mL
	20 mM	0.1679 mL	0.8394 mL	1.6789 mL	4.1972 mL
	25 mM	0.1343 mL	0.6715 mL	1.3431 mL	3.3577 mL
	30 mM	0.1119 mL	0.5596 mL	1.1192 mL	2.7981 mL
Ethanol	40 mM	0.0839 mL	0.4197 mL	0.8394 mL	2.0986 mL
Ethanol	50 mM	0.0672 mL	0.3358 mL	0.6715 mL	1.6789 mL

Bufuralol hydrochloride Related Classifications

Endocrinology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bufuralol60398-91-6Ro 3-4787Adrenergic ReceptorBeta ReceptorCYP2D6probesubstratenon-selectiveorallyβ-adrenoreceptorInhibitorinhibitorinhibit

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Bufuralol hydrochloride (Synonyms: Ro 3-4787 hydrochloride)

Customer Review

Other Forms of Bufuralol hydrochloride:

Bufuralol hydrochloride Related Antibodies

1 Publications Citing Use of MCE Bufuralol hydrochloride

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Adrenergic Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Bufuralol hydrochloride Related Antibodies

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Dilution Calculator

Complete Stock Solution Preparation Table

Bufuralol hydrochloride Related Classifications

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