2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling MAPK/ERK Pathway
  3. JAK STAT p38 MAPK
  4. Butyzamide

Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay.

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Butyzamide Chemical Structure

Butyzamide Chemical Structure

CAS No. : 1110767-45-7

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Based on 1 publication(s) in Google Scholar

Butyzamide Related Antibodies

Top Publications Citing Use of Products

View All JAK Isoform Specific Products:

View All Isoforms
JAK1 JAK2 JAK3 Tyk2 JAK

View All STAT Isoform Specific Products:

View All Isoforms
STAT3 STAT5 STAT6 STAT1

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1].

IC50 & Target

JAK2

 

STAT3

 

STAT5

 

In Vitro

Butyzamide (3 μM; 15 min) induces the phosphorylation of JAK2, STAT3, STAT5 and MAPK in Ba/F3-hMpl cells[1].
Butyzamide (3 μM; 48 h) induces colony-forming unit-megakaryocyte and polyploid meggakaryocytes from human CD34+ hematopoietic progenitor cellls[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Butyzamide Related Antibodies
In Vivo

Butyzamide (10 mg/kg, 50 mg/kg; p.o.; once daily for 20 days) increases human platelets in NOG mice transplanted with human fetal liver-derived CD34+ cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

591.55

Formula

C29H32Cl2N2O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCOC(C(C)(C)C)C1=CC=CC(C2=CSC(NC(C3=CC(Cl)=C(/C=C(C(O)=O)\C)C(Cl)=C3)=O)=N2)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (169.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6905 mL 8.4524 mL 16.9047 mL
5 mM 0.3381 mL 1.6905 mL 3.3809 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6905 mL 8.4524 mL 16.9047 mL 42.2619 mL
5 mM 0.3381 mL 1.6905 mL 3.3809 mL 8.4524 mL
10 mM 0.1690 mL 0.8452 mL 1.6905 mL 4.2262 mL
15 mM 0.1127 mL 0.5635 mL 1.1270 mL 2.8175 mL
20 mM 0.0845 mL 0.4226 mL 0.8452 mL 2.1131 mL
25 mM 0.0676 mL 0.3381 mL 0.6762 mL 1.6905 mL
30 mM 0.0563 mL 0.2817 mL 0.5635 mL 1.4087 mL
40 mM 0.0423 mL 0.2113 mL 0.4226 mL 1.0565 mL
50 mM 0.0338 mL 0.1690 mL 0.3381 mL 0.8452 mL
60 mM 0.0282 mL 0.1409 mL 0.2817 mL 0.7044 mL
80 mM 0.0211 mL 0.1057 mL 0.2113 mL 0.5283 mL
100 mM 0.0169 mL 0.0845 mL 0.1690 mL 0.4226 mL
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Butyzamide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Butyzamide1110767-45-7JAKSTATp38 MAPKJanus kinaseInhibitorinhibitorinhibit

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