2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Cyclic AMP

Cyclic AMP  (Synonyms: Cyclic adenosine monophosphate; Adenosine cyclic 3', 5'-monophosphate; cAMP)

Cat. No.: HY-B1511 Purity: 99.95%
SDS COA Handling Instructions

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Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes.

For research use only. We do not sell to patients.

Cyclic AMP Chemical Structure

Cyclic AMP Chemical Structure

CAS No. : 60-92-4

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500 mg USD 60 In-stock
1 g USD 100 In-stock
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Based on 10 publication(s) in Google Scholar

Other Forms of Cyclic AMP:

Cyclic AMP Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Cyclic AMP (Cyclic adenosine monophosphate), adenosine triphosphate derivative, is an intracellular signaling molecule responsible for directing cellular responses to extracellular signals. Cyclic AMP is an important second messenger in many biological processes[1][2][3].

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Cyclic AMP (Cyclic adenosine monophosphate) modulates mediator generation. Cyclic AMP suppresses the expression of pro-inflammatory cytokines, including TNF-α and IL-12, and enhances the production of the anti-inflammatory cytokine IL-10.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cyclic AMP Related Antibodies
Clinical Trial
Molecular Weight

329.21

Formula

C10H12N5O6P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=C2N=CN([C@@H]3O[C@]4([H])COP(O)(O[C@@]4([H])[C@H]3O)=O)C2=NC=N1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.1 M NaOH : 30 mg/mL (91.13 mM; ultrasonic and adjust pH to 6 with NaOH)

H2O : 2.4 mg/mL (7.29 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0376 mL 15.1879 mL 30.3757 mL
5 mM 0.6075 mL 3.0376 mL 6.0751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

SDS (476 KB)

COA (256 KB) HNMR (266 KB) CNMR (317 KB) RP-HPLC (267 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.1 M NaOH 1 mM 3.0376 mL 15.1879 mL 30.3757 mL 75.9394 mL
5 mM 0.6075 mL 3.0376 mL 6.0751 mL 15.1879 mL
0.1 M NaOH 10 mM 0.3038 mL 1.5188 mL 3.0376 mL 7.5939 mL
15 mM 0.2025 mL 1.0125 mL 2.0250 mL 5.0626 mL
20 mM 0.1519 mL 0.7594 mL 1.5188 mL 3.7970 mL
25 mM 0.1215 mL 0.6075 mL 1.2150 mL 3.0376 mL
30 mM 0.1013 mL 0.5063 mL 1.0125 mL 2.5313 mL
40 mM 0.0759 mL 0.3797 mL 0.7594 mL 1.8985 mL
50 mM 0.0608 mL 0.3038 mL 0.6075 mL 1.5188 mL
60 mM 0.0506 mL 0.2531 mL 0.5063 mL 1.2657 mL
80 mM 0.0380 mL 0.1898 mL 0.3797 mL 0.9492 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclic AMP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclic AMP60-92-4Cyclic adenosine monophosphate Adenosine cyclic 3', 5'-monophosphate cAMPEndogenous Metabolitesecond messengerbiological processesderivativeadenosine triphosphatesignal transductionInhibitorinhibitorinhibit

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