2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Camptothecin-20(S)-O-propionate

Camptothecin-20(S)-O-propionate  (Synonyms: Camptothecin-20-O-propionate)

Cat. No.: HY-114668 Purity: 99.55%
SDS COA Handling Instructions

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Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.

For research use only. We do not sell to patients.

Camptothecin-20(S)-O-propionate Chemical Structure

Camptothecin-20(S)-O-propionate Chemical Structure

CAS No. : 194414-69-2

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Based on 1 publication(s) in Google Scholar

Other Forms of Camptothecin-20(S)-O-propionate:

Camptothecin-20(S)-O-propionate Related Antibodies

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Description

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor[1][2][3].

In Vivo

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm3)[3].
Dosage: 100-1000 mg/kg/day.
Administration: Oral gavage, for 2, 4 and 6 days, respectively.
Result: Exhibited anti-tumor effect.
Molecular Weight

404.42

Formula

C23H20N2O5
CAS No.
Appearance

Solid

Color

Off-white to gray

SMILES

O=C1[C@](CC)(C2=C(C(N3CC4=CC5=CC=CC=C5N=C4C3=C2)=O)CO1)OC(CC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 9.09 mg/mL (22.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4727 mL 12.3634 mL 24.7268 mL
5 mM 0.4945 mL 2.4727 mL 4.9454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.55%

SDS (251 KB)

COA (258 KB) HNMR (115 KB) LCMS (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4727 mL 12.3634 mL 24.7268 mL 61.8169 mL
5 mM 0.4945 mL 2.4727 mL 4.9454 mL 12.3634 mL
10 mM 0.2473 mL 1.2363 mL 2.4727 mL 6.1817 mL
15 mM 0.1648 mL 0.8242 mL 1.6485 mL 4.1211 mL
20 mM 0.1236 mL 0.6182 mL 1.2363 mL 3.0908 mL
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Camptothecin-20(S)-O-propionate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Camptothecin-20(S)-O-propionate194414-69-2Camptothecin-20-O-propionateTopoisomeraseCLObreastcarcinomaPC3prostateInhibitorinhibitorinhibit

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