CAY 10462 dihydrochloride

Name: CAY 10462 dihydrochloride
Brand: MedChemExpress
SKU: HY-120648A
Rating: 4.5 (1 reviews)

Cat. No.: HY-120648A Purity: 98.02%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CAY 10434 dihydrochloride is a potent CYP4A hydroxylase inhibitor. CAY 10434 dihydrochloride improves contractile response to angiotensin II with the maximal contractile response (E_max) 6764 mg.

For research use only. We do not sell to patients.

CAY 10462 dihydrochloride Chemical Structure

CAS No. : 502656-68-0

Size	Price	Stock	Quantity
5 mg	USD 103	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 436	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
100 mg		Get quote
200 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CAY 10462 dihydrochloride:

CAY 10434 Get quote

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•Related Screening Libraries:

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

CAY 10434 dihydrochloride is a potent CYP4A hydroxylase inhibitor. CAY 10434 dihydrochloride improves contractile response to angiotensin II with the maximal contractile response (E_max) 6764 mg^[1].

IC₅₀ & Target

CYP4A hydroxylase^[1]

In Vitro

CAY 10434 dihydrochloride (1 µM; 30 min) combines micoanzol to increase the cumulative angiotensin II in endothelium-intact aortic rings ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

360.32

Formula

C₁₇H₂₇Cl₂N₃O

CAS No.

502656-68-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

CN(CCCCCCOC1=CC=C(C=C1)N2C=CN=C2)C.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 35.71 mg/mL (99.11 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7753 mL	13.8766 mL	27.7531 mL
5 mM	0.5551 mL	2.7753 mL	5.5506 mL
10 mM	0.2775 mL	1.3877 mL	2.7753 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (5.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.02%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (245 KB) HNMR (266 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Jerez S, et al. 17-Octadecynoic acid improves contractile response to angiotensin II by releasing vasocontrictor prostaglandins. Prostaglandins Other Lipid Mediat. 2012 Jan;97(1-2):36-42. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7753 mL	13.8766 mL	27.7531 mL	69.3828 mL
	5 mM	0.5551 mL	2.7753 mL	5.5506 mL	13.8766 mL
	10 mM	0.2775 mL	1.3877 mL	2.7753 mL	6.9383 mL
	15 mM	0.1850 mL	0.9251 mL	1.8502 mL	4.6255 mL
	20 mM	0.1388 mL	0.6938 mL	1.3877 mL	3.4691 mL
	25 mM	0.1110 mL	0.5551 mL	1.1101 mL	2.7753 mL
	30 mM	0.0925 mL	0.4626 mL	0.9251 mL	2.3128 mL
	40 mM	0.0694 mL	0.3469 mL	0.6938 mL	1.7346 mL
	50 mM	0.0555 mL	0.2775 mL	0.5551 mL	1.3877 mL
	60 mM	0.0463 mL	0.2313 mL	0.4626 mL	1.1564 mL
	80 mM	0.0347 mL	0.1735 mL	0.3469 mL	0.8673 mL