2. Cell Cycle/DNA Damage PROTAC
  3. CDK Ligands for Target Protein for PROTAC
  4. CDK9-IN-10

CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811).

For research use only. We do not sell to patients.

CDK9-IN-10 Chemical Structure

CDK9-IN-10 Chemical Structure

CAS No. : 3542-63-0

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Based on 1 publication(s) in Google Scholar

CDK9-IN-10 Related Antibodies

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  • Biological Activity

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Description

CDK9-IN-10 is a potent CDK9 inhibitor. CDK9-IN-10 is the ligand for the PROTAC CDK9 degrader-2 (HY-112811)[1].

IC50 & Target[1]

CDK9

 

Molecular Weight

360.36

Formula

C22H16O5
CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

OC1=C2C(C(C=C(C3=CC=CC=C3)O2)=O)=C(O)C=C1OCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (277.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7750 mL 13.8750 mL 27.7500 mL
5 mM 0.5550 mL 2.7750 mL 5.5500 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7750 mL 13.8750 mL 27.7500 mL 69.3751 mL
5 mM 0.5550 mL 2.7750 mL 5.5500 mL 13.8750 mL
10 mM 0.2775 mL 1.3875 mL 2.7750 mL 6.9375 mL
15 mM 0.1850 mL 0.9250 mL 1.8500 mL 4.6250 mL
20 mM 0.1388 mL 0.6938 mL 1.3875 mL 3.4688 mL
25 mM 0.1110 mL 0.5550 mL 1.1100 mL 2.7750 mL
30 mM 0.0925 mL 0.4625 mL 0.9250 mL 2.3125 mL
40 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.7344 mL
50 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3875 mL
60 mM 0.0463 mL 0.2313 mL 0.4625 mL 1.1563 mL
80 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8672 mL
100 mM 0.0278 mL 0.1388 mL 0.2775 mL 0.6938 mL
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CDK9-IN-10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK9-IN-103542-63-0CDKLigands for Target Protein for PROTACCyclin dependent kinaseTarget Protein-binding MoietyantitumoractivityWogonin-baseddegradationCDK9Inhibitorinhibitorinhibit

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