2. Others GPCR/G Protein Neuronal Signaling
  3. Isotope-Labeled Compounds Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor
  4. Clozapine-d4

Clozapine-d4  (Synonyms: HF 1854-d4)

Cat. No.: HY-14539S2 Purity: 99.82%
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Clozapine-d4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].

For research use only. We do not sell to patients.

Clozapine-d<sub>4</sub> Chemical Structure

Clozapine-d4 Chemical Structure

CAS No. : 204395-52-8

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Based on 1 publication(s) in Google Scholar

Other Forms of Clozapine-d4:

Clozapine-d4 Related Antibodies

Top Publications Citing Use of Products

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

View All mAChR Isoform Specific Products:

View All Isoforms
mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms
α adrenergic receptor β adrenergic receptor

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • Biological Activity

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Description

Clozapine-d4 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4][5].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clozapine-d4 Related Antibodies
Molecular Weight

330.85

Formula

C18H15D4ClN4
CAS No.
Unlabeled CAS

5786-21-0
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1CC([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)C([2H])([2H])C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 10 mg/mL (30.23 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 10 mg/mL (30.23 mM)

DMF : ≥ 10 mg/mL (30.23 mM)

Ethanol : ≥ 5 mg/mL (15.11 mM)

Ethanol : ≥ 5 mg/mL (15.11 mM)

DMSO:PBS(pH7.2) (1:1) : ≥ 0.5 mg/mL (1.51 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0225 mL 15.1126 mL 30.2252 mL
5 mM 0.6045 mL 3.0225 mL 6.0450 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO:PBS(pH7.2) (1:1) / Ethanol / Ethanol / DMSO / DMF / DMF 1 mM 3.0225 mL 15.1126 mL 30.2252 mL 75.5629 mL
Ethanol / Ethanol / DMSO / DMF / DMF 5 mM 0.6045 mL 3.0225 mL 6.0450 mL 15.1126 mL
10 mM 0.3023 mL 1.5113 mL 3.0225 mL 7.5563 mL
15 mM 0.2015 mL 1.0075 mL 2.0150 mL 5.0375 mL
DMSO / DMF / DMF 20 mM 0.1511 mL 0.7556 mL 1.5113 mL 3.7781 mL
25 mM 0.1209 mL 0.6045 mL 1.2090 mL 3.0225 mL
30 mM 0.1008 mL 0.5038 mL 1.0075 mL 2.5188 mL
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Clozapine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clozapine-d4204395-52-8HF 1854-d4Isotope-Labeled CompoundsDopamine ReceptormAChRAdrenergic Receptor5-HT ReceptorMuscarinic acetylcholine receptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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