2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor mAChR Adrenergic Receptor 5-HT Receptor
  4. Clozapine-d8

Clozapine-d8  (Synonyms: HF 1854-d8)

Cat. No.: HY-14539S Purity: 99.68%
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Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4].

For research use only. We do not sell to patients.

Clozapine-d<sub>8</sub> Chemical Structure

Clozapine-d8 Chemical Structure

CAS No. : 1185053-50-2

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1 mg USD 210 In-stock
5 mg USD 690 In-stock
10 mg USD 1150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Clozapine-d8:

Clozapine-d8 Related Antibodies

Top Publications Citing Use of Products

View All Dopamine Receptor Isoform Specific Products:

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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α adrenergic receptor β adrenergic receptor

View All 5-HT Receptor Isoform Specific Products:

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

Clozapine-d8 is the deuterium labeled Clozapine. Clozapine is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clozapine-d8 Related Antibodies
Molecular Weight

334.87

Formula

C18H11D8ClN4
CAS No.
Unlabeled CAS

5786-21-0
Appearance

Solid

Color

Light yellow to yellow

SMILES

CN1C([2H])([2H])C([2H])([2H])N(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C24)C([2H])([2H])C1([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (149.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 50 mg/mL (149.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9862 mL 14.9312 mL 29.8623 mL
5 mM 0.5972 mL 2.9862 mL 5.9725 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 2.9862 mL 14.9312 mL 29.8623 mL 74.6558 mL
5 mM 0.5972 mL 2.9862 mL 5.9725 mL 14.9312 mL
10 mM 0.2986 mL 1.4931 mL 2.9862 mL 7.4656 mL
15 mM 0.1991 mL 0.9954 mL 1.9908 mL 4.9771 mL
20 mM 0.1493 mL 0.7466 mL 1.4931 mL 3.7328 mL
25 mM 0.1194 mL 0.5972 mL 1.1945 mL 2.9862 mL
30 mM 0.0995 mL 0.4977 mL 0.9954 mL 2.4885 mL
40 mM 0.0747 mL 0.3733 mL 0.7466 mL 1.8664 mL
50 mM 0.0597 mL 0.2986 mL 0.5972 mL 1.4931 mL
60 mM 0.0498 mL 0.2489 mL 0.4977 mL 1.2443 mL
80 mM 0.0373 mL 0.1866 mL 0.3733 mL 0.9332 mL
100 mM 0.0299 mL 0.1493 mL 0.2986 mL 0.7466 mL
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Clozapine-d8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clozapine-d81185053-50-2HF 1854-d8Dopamine ReceptormAChRAdrenergic Receptor5-HT ReceptorMuscarinic acetylcholine receptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorantipsychoticmuscarinicbehavioralInhibitorinhibitorinhibit

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