2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Cortistatin-29 (reduced)

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.

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Cortistatin-29 (reduced) Chemical Structure

Cortistatin-29 (reduced) Chemical Structure

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Based on 1 publication(s) in Google Scholar

Cortistatin-29 (reduced) Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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Description

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects[1][2][3][4].

IC50 & Target[3]

SSTR1

2.8 nM (IC50)

SSTR2

7.1 nM (IC50)

SSTR3

0.2 nM (IC50)

SSTR4

3.0 nM (IC50)

SSTR5

13.7 nM (IC50)

In Vivo

Cortistatin 29 (1-2 µg) alleviates chronic neuropathic pain in mouse[1].
Cortistatin 29 (1 nmol/mouse; i.p.; three times weekly) shows anti-fibrotic effects in mouse[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 20-24 g body weight, 8-12 weeks-old mice[1]
Dosage: 1 µg in 20 µL for s.c.; 2 µg in 200 µL for i.p.; 20 ng in 10 µL for i.t.
Administration: Every other day for 12 days
Result: Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.
Animal Model: 20-24g body weight, 8-10 weeks-old C57BL/6 mice (CST+/+, CST+/- and CST-/- mice)[4].
Dosage: 1 nmol/mouse
Administration: I.p., three times weekly from 5 or 14 days
Result: Reversed in vivo and in vitro these exaggerated fibrogenic phenotypes and protected from progression to severe liver fibrosis in response to hepatic injury.
Molecular Weight

3539.77

Formula

C161H242N46O41S2
Appearance

Solid

Color

White to off-white

Sequence Shortening

{Glp}-ERPPLQQPPHRDKKPCKNFFWKTFSSCK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (28.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2825 mL 1.4125 mL 2.8250 mL
5 mM 0.0565 mL 0.2825 mL 0.5650 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2825 mL 1.4125 mL 2.8250 mL 7.0626 mL
5 mM 0.0565 mL 0.2825 mL 0.5650 mL 1.4125 mL
10 mM 0.0283 mL 0.1413 mL 0.2825 mL 0.7063 mL
15 mM 0.0188 mL 0.0942 mL 0.1883 mL 0.4708 mL
20 mM 0.0141 mL 0.0706 mL 0.1413 mL 0.3531 mL
25 mM 0.0113 mL 0.0565 mL 0.1130 mL 0.2825 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cortistatin-29 (reduced) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cortistatin-29 (reduced)Somatostatin ReceptorSSTRsSSTRanti-fibroticneuropathic painneuropeptidecontractile fibersInhibitorinhibitorinhibit

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