CuATSM 

CuATSM is a copper complex that scavenges free radicals, inhibits lipid peroxidation and ferroptosis. CuATSM exhibits antioxidant, anti-inflammatory and neuroprotective activities^[1][2].

CuATSM (1 nM-1 μM, 4.5 h) inhibits RSL3 (HY-100218A)-induced ferroptosis with an EC₅₀ of 160 nM in Pfa1 mouse embryonic fibroblasts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CuATSM (1.5 mg/kg, iv, single dose) reduces cerebral infarct volume and oxidative stress, exhibits neuroprotective effect against ischemic stroke in mouse model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

321.91

C₈H₁₄CuN₆S₂

68341-09-3

Solid

Light brown to brown

CC1=[N]2[N-]C(NC)=[S][Cu+2]32[S]=C(NC)[N-][N]3=C1C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Zilka O, et al. Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. J Am Chem Soc. 2021 Nov 17;143(45):19043-19057.  [Content Brief]

  [2]. Shi X, et al., Neuroprotective effect of CuATSM in mice stroke model by ameliorating oxidative stress. Neurosci Res. 2021 May;166:55-61.  [Content Brief]