CXCR2 antagonist 2

Name: CXCR2 antagonist 2
Brand: MedChemExpress
SKU: HY-139873
Rating: 4.5 (1 reviews)

Cat. No.: HY-139873 Purity: 99.12%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC₅₀ value of 95 nM.

For research use only. We do not sell to patients.

CXCR2 antagonist 2 Chemical Structure

CAS No. : 2647464-91-1

Size	Price	Stock	Quantity
5 mg	USD 500	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1800	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 3000	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4600	In-stock	Estimated Time of Arrival: December 31
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500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunoresearch with an IC₅₀ value of 95 nM.

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	> 10 μM Compound: 9b	Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
MIA PaCa-2	IC₅₀	> 10 μM Compound: 9b	Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
PANC-1	IC₅₀	> 10 μM Compound: 9b	Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
PBMC	IC₅₀	> 10 μM Compound: 9b	Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
SW1990	IC₅₀	> 10 μM Compound: 9b	Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]

Molecular Weight

364.39

Formula

C₁₇H₁₇FN₂O₄S

CAS No.

2647464-91-1

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S1(C2=C(O)C(NC(NC3=CC=CC(F)=C3C)=O)=CC=C2CCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (274.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7443 mL	13.7216 mL	27.4431 mL
5 mM	0.5489 mL	2.7443 mL	5.4886 mL
10 mM	0.2744 mL	1.3722 mL	2.7443 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.86 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.12%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) HNMR (439 KB) RP-HPLC (261 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021 Nov 25;64(22):16626-16640. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7443 mL	13.7216 mL	27.4431 mL	68.6078 mL
	5 mM	0.5489 mL	2.7443 mL	5.4886 mL	13.7216 mL
	10 mM	0.2744 mL	1.3722 mL	2.7443 mL	6.8608 mL
	15 mM	0.1830 mL	0.9148 mL	1.8295 mL	4.5739 mL
	20 mM	0.1372 mL	0.6861 mL	1.3722 mL	3.4304 mL
	25 mM	0.1098 mL	0.5489 mL	1.0977 mL	2.7443 mL
	30 mM	0.0915 mL	0.4574 mL	0.9148 mL	2.2869 mL
	40 mM	0.0686 mL	0.3430 mL	0.6861 mL	1.7152 mL
	50 mM	0.0549 mL	0.2744 mL	0.5489 mL	1.3722 mL
	60 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1435 mL
	80 mM	0.0343 mL	0.1715 mL	0.3430 mL	0.8576 mL
	100 mM	0.0274 mL	0.1372 mL	0.2744 mL	0.6861 mL