2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP1B1-IN-4

CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes.

For research use only. We do not sell to patients.

CYP1B1-IN-4 Chemical Structure

CYP1B1-IN-4 Chemical Structure

CAS No. : 2685779-55-7

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Based on 1 publication(s) in Google Scholar

CYP1B1-IN-4 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Description

CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectively CYP1B1 inhibition (IC50=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes[1].

IC50 & Target[1]

CYP1B1

0.2 nM (IC50)

CYP1A1

3.98 μM (IC50)

In Vitro

CYP1B1-IN-4 (compound 15) (100 μM; 37 ℃; 0-60 min) has in vitro stability in both human and rat liver microsomes, while it has low stability in mouse liver microsomes[1].
CYP1B1-IN-4 (1 nM-10 μM) also inhibits CYP1A1 with an IC50 value of 3.82 μM[1].
CYP1B1-IN-4 (200 μM; 72 h) parental HEK T-REx cell line , and (100 μ M; 72 h) has little cytotoxicity in HEK293 cells[1].

Stability Parameters in Human, Rat, or Mouse Liver Microsomes[1]

Parameters T1/2 (min) CLint(mic) (μL/min/mg) CLint(liver) (mL/min/kg) % remainingT=60 min
Human 28.3 49.0 44.1 19.0
Rat 36.6 37.9 68.2 27.1
Mouse 2.5 545.9 2161.9 0.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYP1B1-IN-4 Related Antibodies
Molecular Weight

322.38

Formula

C18H14N2O2S
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

COC1=CC=C(C(OC)=C1)C2=NC(C3=CC=C(C=C3)C#N)=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (193.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1019 mL 15.5096 mL 31.0193 mL
5 mM 0.6204 mL 3.1019 mL 6.2039 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1019 mL 15.5096 mL 31.0193 mL 77.5482 mL
5 mM 0.6204 mL 3.1019 mL 6.2039 mL 15.5096 mL
10 mM 0.3102 mL 1.5510 mL 3.1019 mL 7.7548 mL
15 mM 0.2068 mL 1.0340 mL 2.0680 mL 5.1699 mL
20 mM 0.1551 mL 0.7755 mL 1.5510 mL 3.8774 mL
25 mM 0.1241 mL 0.6204 mL 1.2408 mL 3.1019 mL
30 mM 0.1034 mL 0.5170 mL 1.0340 mL 2.5849 mL
40 mM 0.0775 mL 0.3877 mL 0.7755 mL 1.9387 mL
50 mM 0.0620 mL 0.3102 mL 0.6204 mL 1.5510 mL
60 mM 0.0517 mL 0.2585 mL 0.5170 mL 1.2925 mL
80 mM 0.0388 mL 0.1939 mL 0.3877 mL 0.9694 mL
100 mM 0.0310 mL 0.1551 mL 0.3102 mL 0.7755 mL
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CYP1B1-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP1B1-IN-42685779-55-7Cytochrome P450CYPsInhibitorinhibitorinhibit

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