2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. Dacomitinib hydrate

Dacomitinib hydrate  (Synonyms: PF-00299804 hydrate; PF-299804 hydrate)

Cat. No.: HY-118263 Purity: 99.03%
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Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan-ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

Dacomitinib hydrate Chemical Structure

Dacomitinib hydrate Chemical Structure

CAS No. : 1042385-75-0

Size Price Stock Quantity
5 mg USD 90 In-stock
10 mg USD 150 In-stock
50 mg USD 290 In-stock
100 mg USD 450 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 21 publication(s) in Google Scholar

Other Forms of Dacomitinib hydrate:

Dacomitinib hydrate Related Antibodies

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dacomitinib (PF-00299804) hydrate is an orally active, irreversible pan-ErbB inhibitor. Dacomitinib hydrate can be used in the research of cancers such as metastatic non-small cell lung cancer (NSCLC)[1].

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
46 nM
Compound: 25, PF-00299804
Inhibition of GST-tagged ErbB2 expressed in sf9 cells by ELISA
Inhibition of GST-tagged ErbB2 expressed in sf9 cells by ELISA
[PMID: 22621397]
Sf9 IC50
6 nM
Compound: 25, PF-00299804
Inhibition of GST-tagged EGFR expressed in sf9 cells by ELISA
Inhibition of GST-tagged EGFR expressed in sf9 cells by ELISA
[PMID: 22621397]
Sf9 IC50
74 nM
Compound: 25, PF-00299804
Inhibition of GST-tagged ErbB4 expressed in sf9 cells by ELISA
Inhibition of GST-tagged ErbB4 expressed in sf9 cells by ELISA
[PMID: 22621397]
Clinical Trial
Molecular Weight

487.95

Formula

C24H27ClFN5O3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(/C=C/CN1CCCCC1)NC2=CC3=C(C=C2OC)N=CN=C3NC4=CC=C(C(Cl)=C4)F.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 48.33 mg/mL (99.05 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0494 mL 10.2470 mL 20.4939 mL
5 mM 0.4099 mL 2.0494 mL 4.0988 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0494 mL 10.2470 mL 20.4939 mL 51.2348 mL
5 mM 0.4099 mL 2.0494 mL 4.0988 mL 10.2470 mL
10 mM 0.2049 mL 1.0247 mL 2.0494 mL 5.1235 mL
15 mM 0.1366 mL 0.6831 mL 1.3663 mL 3.4157 mL
20 mM 0.1025 mL 0.5123 mL 1.0247 mL 2.5617 mL
25 mM 0.0820 mL 0.4099 mL 0.8198 mL 2.0494 mL
30 mM 0.0683 mL 0.3416 mL 0.6831 mL 1.7078 mL
40 mM 0.0512 mL 0.2562 mL 0.5123 mL 1.2809 mL
50 mM 0.0410 mL 0.2049 mL 0.4099 mL 1.0247 mL
60 mM 0.0342 mL 0.1708 mL 0.3416 mL 0.8539 mL
80 mM 0.0256 mL 0.1281 mL 0.2562 mL 0.6404 mL
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Dacomitinib hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dacomitinib1042385-75-0PF-00299804PF-299804PF00299804PF 00299804PF299804PF 299804EGFREpidermal growth factor receptorErbB-1HER1NSCLCcancertumorInhibitorinhibitorinhibit

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