DBCO-PEG4-MMAF

Name: DBCO-PEG4-MMAF
Brand: MedChemExpress
SKU: HY-133492
Rating: 4.5 (1 reviews)

Cat. No.: HY-133492 Purity: 99.80%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

DBCO-PEG4-MMAF is a agent-linker conjugate for ADC with potent antitumor activity by using the tubulin polymerization inhibitor, MMAF, linked via the cleavable linker DBCO-PEG4. DBCO-PEG4-MMAF is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG4-MMAF Chemical Structure

CAS No. : 2360411-65-8

Size	Price	Stock	Quantity
5 mg	USD 405	In-stock	Estimated Time of Arrival: May 5
10 mg	USD 650	In-stock	Estimated Time of Arrival: May 5
50 mg		Get quote
100 mg		Get quote

Get it by May 5 for select sizes. Order within 17 hrs 32 mins.

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Based on 1 publication(s) in Google Scholar

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Biological Activity
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Description

IC₅₀ & Target

Auristatin

In Vitro

Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1266.56

Formula

C₆₉H₉₉N₇O₁₅

CAS No.

2360411-65-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@]([C@@H](C)CC)([H])[C@H](OC)CC(N(CCC4)[C@]4([H])[C@H](OC)[C@@H](C)C(N[C@H](C(O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (78.95 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.7895 mL	3.9477 mL	7.8954 mL
5 mM	0.1579 mL	0.7895 mL	1.5791 mL
10 mM	0.0790 mL	0.3948 mL	0.7895 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 5 mg/mL (3.95 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 5 mg/mL (3.95 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (3.95 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (251 KB) SDS (252 KB)

COA (255 KB) HNMR (252 KB) RP-HPLC (249 KB) MS (70 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.7895 mL	3.9477 mL	7.8954 mL	19.7385 mL
	5 mM	0.1579 mL	0.7895 mL	1.5791 mL	3.9477 mL
	10 mM	0.0790 mL	0.3948 mL	0.7895 mL	1.9739 mL
	15 mM	0.0526 mL	0.2632 mL	0.5264 mL	1.3159 mL
	20 mM	0.0395 mL	0.1974 mL	0.3948 mL	0.9869 mL
	25 mM	0.0316 mL	0.1579 mL	0.3158 mL	0.7895 mL
	30 mM	0.0263 mL	0.1316 mL	0.2632 mL	0.6580 mL
	40 mM	0.0197 mL	0.0987 mL	0.1974 mL	0.4935 mL
	50 mM	0.0158 mL	0.0790 mL	0.1579 mL	0.3948 mL
	60 mM	0.0132 mL	0.0658 mL	0.1316 mL	0.3290 mL

DBCO-PEG4-MMAF Related Classifications

Keywords:

DBCO-PEG4-MMAF2360411-65-8Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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DBCO-PEG4-MMAF

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Biological Activity

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

DBCO-PEG4-MMAF Related Classifications

Keywords:

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SAFETY DATA SHEET (SDS)

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