2. Immunology/Inflammation
  3. COX
  4. Diclofenac epolamine

Diclofenac epolamine  (Synonyms: Diclofenac hydroxyethylpyrrolidine)

Cat. No.: HY-109547 Purity: 99.95%
COA Handling Instructions

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Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID). Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies.

For research use only. We do not sell to patients.

Diclofenac epolamine Chemical Structure

Diclofenac epolamine Chemical Structure

CAS No. : 119623-66-4

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 55 In-stock
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10 mg USD 50 In-stock
25 mg USD 90 In-stock
50 mg USD 140 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Diclofenac epolamine Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID)[1]. Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies[2].

In Vitro

Flector Patch (Diclofenac epolamine) (1.3% w/w, 24 hours) increases diclofenac partitioning into the skin[1].
Flector Patch (Diclofenac epolamine) (1.3% w/w) loaded by Microemulsion (ME) enhances the transport of drug through skin and sustains to 12 h after removal of ME[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diclofenac epolamine Related Antibodies
In Vivo

Flector Patch (Diclofenac epolamine) (1.3% w/w, exteral application) displays effective in treating inflammatory conditions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat paw edema inflammation model (induced with carrageenan)[2]
Dosage: 1.3% w/w
Administration: Exteral application
Result: Inhibited edema and showed anti-inflammatory efficacy at 6 hours after application.
Clinical Trial
Molecular Weight

411.32

Formula

C20H24Cl2N2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OCCN1CCCC1.OC(CC(C=CC=C2)=C2NC3=C(C=CC=C3Cl)Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (243.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4312 mL 12.1560 mL 24.3120 mL
5 mM 0.4862 mL 2.4312 mL 4.8624 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (12.16 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.95%

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4312 mL 12.1560 mL 24.3120 mL 60.7799 mL
5 mM 0.4862 mL 2.4312 mL 4.8624 mL 12.1560 mL
10 mM 0.2431 mL 1.2156 mL 2.4312 mL 6.0780 mL
15 mM 0.1621 mL 0.8104 mL 1.6208 mL 4.0520 mL
20 mM 0.1216 mL 0.6078 mL 1.2156 mL 3.0390 mL
25 mM 0.0972 mL 0.4862 mL 0.9725 mL 2.4312 mL
30 mM 0.0810 mL 0.4052 mL 0.8104 mL 2.0260 mL
40 mM 0.0608 mL 0.3039 mL 0.6078 mL 1.5195 mL
50 mM 0.0486 mL 0.2431 mL 0.4862 mL 1.2156 mL
60 mM 0.0405 mL 0.2026 mL 0.4052 mL 1.0130 mL
80 mM 0.0304 mL 0.1519 mL 0.3039 mL 0.7597 mL
100 mM 0.0243 mL 0.1216 mL 0.2431 mL 0.6078 mL
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Diclofenac epolamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diclofenac epolamine119623-66-4Diclofenac hydroxyethylpyrrolidineCOXCyclooxygenasenon-steroidal anti-inflammatory agentNSAIDantipyreticanalgesiccutaneous absorptionsurfactant1.3% patchInhibitorinhibitorinhibit

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